第三十八期水木清华生命科学讲座系列
NK Cells and Liver Disease
田志刚博士为中国科技大学生命科学学院教授、医学中心主任、免疫学研究所所长、中国科学院天然免疫与慢性疾病重点实验室主任、中国免疫学会理事长。曾任中国科技大学生命科学学院院长。
1989年国内较早开展NK细胞研究，发现肝脏特有NK细胞及其肝内发育分化新途径，提出“肝脏也是天然免疫器官”；发现NK细胞可通过分泌细胞因子对免疫系统行使整体调节，提出存在“调节性NK细胞（Regulatory NK Cell）”；揭示肝脏乙肝病毒诱发NK细胞免疫耐受，提出“NK细胞识别受体异常可导致肝脏疾病”。试图从NK细胞角度解析肝脏“免疫耐受”奥秘并重新认识肝脏疾病。
受行业专项委托制定国家NK细胞临床应用技术标准，建立可临床应用的国人首株NK细胞系和多种基因修饰亚株、创建自身NK细胞体外千倍级扩增技术、研制NK细胞刺激因子（Interleukin-12）重组蛋白药物等，已进入临床试验申报阶段。2008年获国家自然科学二等奖、2011年获国家科技进步二等奖、2015年获何梁何基金利科技进步奖。
Speaker: Zhigang Tian, M.D., Ph.D.
Director and Professor
Abstract:
Liver was recently recognized as an innate immune organ since its high content of NK cells, NKT cells and gdT cells in addition to monocyte-derived Kupffer cells. The key immunologic features of liver are considered to be immunotolerant, which keeps liver homeostasis and safeguards its pivotal function. In the last two decades, we tried to explore the liver-specific NK subset, and to clarify its biological, physiological and pathological role in liver tolerance and homeostasis. Recently, we found a liver-resident NK cells which occupys almost 50% of all hepatic NK cells (the rest of NK cells coming from blood circulation, called conventional NK cells), characterized with an unique surface phenotype, absolute localization in liver and development from adult liver heamatopoietic progenitor cells (Liver-HPC). The importance of this liver-resident NK cell, and also other possible liver-HPC-derived innate lymphoid cells such as NKT cells, gdT cells and ILC1, in HBV infection, viral hepatitis and HCC is also discussed. I will present some evidences to demonstrat that like CTLs, NK cell exhaustion also existes in tumor, and chekchpoint molecules found through liver NK cell study play a critical role in immunotherapy.
日期：2月25日（周四）15:00-16:00
地点：清华大学医学科学楼B323
