第四十五期水木清华生命科学讲座系列
姚雪彪博士，1995年获美国加州大学伯克利分校细胞分子生物学博士,。1999年入选国家自然科学基金委“杰出青年基金”。 现为中国科学技术大学教授，安徽省细胞动力学与化学生物学重点实验室主任。作为项目首席科学家主持了973项目“调控细胞增殖重要蛋白质作用网络的研究”（2002-2008）。现为国家自然科学基金委“创新群体”负责人。担任国际期刊《J. Biol. Chem.》、《Cell Discovery》、《Cell Res.》编委，美国Keystone Symposium SAB member。获得多项研究奖，其中包括2015年的“国家自然科学二等奖”。
姚雪彪博士主要致力于细胞有丝分裂的机制研究。细胞有丝分裂是重要的生命活动，包含在染色体中的父代遗传信息通过纺锤体丝与染色体着丝粒的协同作用来完成向子代细胞的均等传送,其精准调控是细胞健康的保证。细胞有丝分裂调控缺陷是肿瘤发生的关键步骤。在过去的十几年中，姚雪彪博士领导的科研团队发现了细胞有丝分裂精准调控的生化通路与其作用机理。根据这些研究成果，姚雪彪博士还研发出针对着丝粒马达蛋白CENP-E的新型小分子抑制剂syntelin,其在部分肿瘤治疗中具有较好的疗效。
Topic: Cell Division and Precision Regulation
Speaker:
Xuebiao Yao, Ph.D.
Cheung Kong Professor and Head
Anhui Key Laboratory for Cellular Dynamics & Chemical Biology, China
Abstract:
Chromosome segregation in mitosis is orchestrated by dynamic interaction between spindle microtubules and the kinetochore, a multiprotein complex assembled onto centromeric DNA of the chromosome. Faithful segregation of chromosomes in mammalian cells requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Our laboratory has been using kinetochore organization and plasticity control to study the biochemical cascade and cellular dynamics that ensure chromosome stability during cell division cycle. The entry into mitosis requires cyclin dependent kinase activation while the regulatory mechanisms that couple CDK1-cyclin B activity to chromosome stability are not well understood. In this seminar, I plan to discuss our recent progress in delineating an acetyl-phosphorylation signaling axis using a combination of chemical biology, biochemistry and biophotonics. We have identified CDK1-TIP60-Aurora B signaling axis which ensures a robust, error-free metaphase-anaphase transition. Moreover, we have identified additional TIP60 effectors in mitosis which ensure the spindle geometry and dynamics. These findings delineate a conserved signaling cascade that integrates protein phosphorylation and acetylation with cell cycle progression for maintenance of genomic stability.
日期：10月13日（周四） 15:00-16:00
地点：清华大学医学科学楼B323
