第五十五期水木清华生命科学讲座系列
陈大华研究员1991年毕业于安徽农业大学，1999年中国科学院植物研究所获得博士学位，2000 -2005年在美国得克萨斯州西南医学中心分子生物学系从事博士后研究。2005年入选“中科院百人计划”回国，现为中科院动物所研究员，中国科学院大学教授。
陈大华研究员长期以果蝇等模式生物为模型，阐明了生殖干细胞命运决定过程中干细胞及其分化子细胞对微环境信号响应梯度形成机理。提出了控制生殖干细胞不对称分裂的“双稳态调控”模型；揭示了细胞发育过程中系统稳定性维持的“双向调控”机制，为一些疾病发生和发病机理研究提供新线索。近年来，陈大华及其合作者在果蝇基因组中首次发现新型DNA修饰形式（6mA）及其动态调控机制，该研究揭示了高等真核生物中表观遗传调控的新途径。陈大华研究员获“2016年度中国科学院杰出科技成就奖”。
Topic: Fate Determination of Germline Stem Cells in Drosophila Ovary
Speaker:
Dahua Chen, Ph.D.
Institute of Zoology, Chinese Academy of Sciences, Beijing
Abstract:
Over the last ten years, my group has been focusing on studying the molecular mechanisms that control asymmetric division of germline stem cells (GSCs) and epigenetic regulation of germline development in Drosophila. Our findings elucidated the molecular basis of how a GSC and its differentiating daughter (CB) differentially respond to niche BMP signal, thus forming a steep gradient of BMP signaling response that controls the GSC fate. By performing mathematic modeling analyses, we found a bistable behavior of the feedback-loop system in controlling fate determination of GSCs and regulating early germ cell development in an irreversible manner. Recently, we identified a novel DNA modification (6mA) in Drosophila and proposed a potential role of the 6mA modification in controlling development in higher eukaryotes. This finding opens a new direction in the fields of developmental biology and epigenetic regulation.
日期：6月8日（周四）15:00-16:00
地点：清华大学医学科学楼B323
