生命科学联合中心
学术报告
Title：Translational Control of Cancer and Neurodevelopmental diseases via eIF4E
Speaker： Nahum Sonenberg, Ph.D.
Gilman Cheney Professor
McGill University, Canada
Department of Biochemistry and the Goodman Cancer Research Centre
Fellow of The Royal Society of Canada, Academy of Science
Foreign Honorary Member of the American Academy of Arts and Sciences
Time：2017-8-28（周一），10:00am-11:30am
Venue：北京大学新生物楼邓佑才报告厅
Host：伊成器 ，北大-清华生命科学联合中心
Translational control plays a critical role in essential cellular processes including cell growth, proliferation, development, and learning and memory. Under most circumstances, translational control is exerted at the initiation step in which the eukaryotic translation initiation factor 4E (eIF4E) interacts with the mRNA 5’cap structure to facilitate the recruitment of ribosomes and promote translation. Importantly, eIF4E preferentially stimulates the translation of a subset of mRNAs. The activity of eIF4E is regulated chiefly by two major signalling pathways: PI3K/Akt/mTOR and Ras/MAPK/Mnk. mTOR directly phosphorylates the 4E-BPs (eIF4E-binding proteins), which are inhibitors of eIF4E, to relieve translational suppression, while Mnk phosphorylates eIF4E to stimulate translation. Aberrations in these pathways result in dysregulated eIF4E activity, which engenders tumorigenesis and neurological disorders such as autism and Fragile X syndrome.
