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专题学术讲座
4月24日北京大学学术讲座—李雪明研究员
发布时间:2018-04-23关键字:

Institute of Molecular Medicine 
Center for Life Sciences 
Research Seminar 

 

Title:Accelerate atomic-resolution electron cryo-microscopy for future large-scale applications

Speaker:李雪明, Ph.D.
                 清华大学生命科学学院研究员

Time:2018年4月24日(星期二)下午1:30-3:00

Place:北京大学英杰交流中心306会议室

Host:生命中心、北京大学分子医学研究所    陈雷 (Tel. 6275-5557)

Abstract: Electron Cryo-Microscopy (CryoEM) is becoming a powerful tool in determining structures of biological macromolecules at atomic resolution. However, the general applicability and efficiency are still challenges, limiting the large-scale applications of CryoEM in the wider ranges of scientific researches and pharmaceutical companies. Under this background, we are developing an automated CryoEM system to enable a high-throughput pipeline for CryoEM structure determination. By introducing machine learning algorithms, including deep learning and particle filter, we tried to make the CryoEM system more intelligent. By parallel computing, we are making the CryoEM faster and more efficient. Besides the single-particle technology, we also worked on a system to solve protein crystal structure by cryoEM.

 




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