网站地图 加入收藏 中文 English
 
首页 中心概况 组织机构 研究队伍 科学研究 人才培养 交流合作 支撑服务 人才招聘 下载专区 联系我们
当前位置:首页 - 交流合作 - 专题学术讲座
专题学术讲座
5月10日清华大学学术报告 - Magdalena Koziol
发布时间:2018-05-08关键字:

 

Identification of a novel DNA modification in eukaryotes: methylated deoxyadenosine (dA6m)

 

Seminar­­­

May 10th (Thursday)

10:00 – 11:00

B321, Med. Sci. Bldg.

 

Magdalena Koziol, Ph.D. 

The Gurdon Institute

 

University of Cambridge

 

Methylation of cytosine deoxynucleotides is a well-established epigenetic mark, but in higher eukaryotes much less is known about modifications affecting other deoxynucleotides. We report the detection of N-6-methyl-deoxyadenosine in vertebrate DNA, such as frogs, but also in other species including mouse and human. Our methylome analysis reveals that dA6m is widely distributed across the eukaryotic genome, is present in different cell types, but commonly depleted from gene exons. Thus, direct DNA modifications might be more widespread than previously thought.

 

Host: Jose C. Pastor-Pareja

 

jose.pastor@biomed.tsinghua.edu.cn

 

 




版权所有 生命科学联合中心