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6月7日北京大学学术报告—Xiaolan Zhao
发布时间:2018-06-02关键字:

 生命科学联合中心

 

学术报告

TitleLearning about genome duplication mechanisms from protein modifications and cancer mutations

Speaker:  Xiaolan Zhao, Ph.D.

Molecular Biology Program

Memorial Sloan-Kettering Cancer Center

Time2018-6-7(周四),13:00 -14:00 pm  

Venue邓佑才报告厅,北京大学金光生命科学大楼

Host李晴北大-清华生命科学联合中心

Abstract

Genome duplication is essential for all life forms, and its deficiencies lead to many types of human diseases, such as chromosomal breakage syndromes, premature aging, and cancers. Faithful duplication of the human genome of three billion base pairs is a challenging process and many steps within are not understood. The yeast system offers great technical advantages, allowing the discoveries of some key mechanisms leading to the assembly of the replication machinery (replisome) and the subsequent new strand synthesis. Building from these findings, we examined how the DNA helicase for unwinding DNA during genome duplication is regulated by protein medication. In addition, we investigated the roles of the DNA polymerase epsilon (Pol ε), a key member of the replication machinery and a newly defined tumor suppressor. We found that cancer-associated mutations at a highly conserved domain of the Pol ε impair replisome assembly and progression and generate specific forms of genomic instability. These findings shed lights on how DNA helicase must be timely regulated, how polymerase functions in multiple steps of genome duplication, and how perturbing these functions can promote tumorigenesis in humans.

 




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