网站地图 加入收藏 中文 English
 
首页 中心概况 组织机构 研究队伍 科学研究 人才培养 交流合作 支撑服务 人才招聘 下载专区 联系我们
当前位置:首页 - 交流合作 - 专题学术讲座
专题学术讲座
6月13日北京大学学术报告-Jiandong Liu
发布时间:2018-06-14关键字:

Institute of Molecular Medicine 
Center for Life Sciences 
Research Seminar 

Title:Mechanical regulation of cardiac morphogenesis and homeostasis

Speaker:Jiandong Liu, Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
McAllister Heart Institute
University of North Carolina at Chapel Hill, USA

Time:2018年6月13日(星期三)下午4:00-5:00

Place:北京大学英杰交流中心306会议室

Host:北京大学分子医学研究所       何爱彬 (Tel. 6276-7275)


Abstract: During pathological hypertrophy, the heart undergoes extensive metabolic changes prior to the onset of structural remodeling, yet, it remains unknown whether and how this metabolic remodeling could contribute to cardiac hypertrophic growth. Here, we identified the RNA-binding protein Lin28a as a critical regulator of pathological cardiac hypertrophy and metabolic re-patterning. Cardiac-specific deletion of Lin28a attenuated pressure overload-induced hypertrophic growth, cardiac dysfunction and alterations in cardiac transcriptome. Mechanistically, Lin28a directly bound to mitochondrial phosphoenolpyruvate carboxykinase 2 (Pck2) mRNA and positively modulated its level. Manipulation of Pck2 expression phenocopied hypertrophic growth phenotypes of manipulating Lin28a expression. Epistatic analysis demonstrated that Pck2 mediated, at least in part, the role of Lin28a in cardiac hypertrophic growth. Furthermore, metabolomic analyses highlighted role for Lin28a and Pck2 in promoting cardiac anabolic biosynthesis required for cell growth. Thus, our study revealed a critical role of Lin28a in the regulation of pathological cardiac hypertrophic growth through Pck2-mediated regulation of cardiac metabolism. 
 




版权所有 生命科学联合中心