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水木清华生命科学讲座系列第70期 - 赵世民
发布时间:2018-09-10关键字:

 

水木清华生命科学讲座系列第70期

 

1.Topic: Amino Acids Signal Deregulation and Human Diseases

2.Photo:

3.Introduction of speaker:

赵世民博士1966年出生于中国四川南充,1988年毕业于北京师范大学,2000年获美国普渡大学生物化学博士。现为复旦大学教授。

自2006年全职回国以来,赵世民博士主要致力于代谢失调与疾病发生机理的研究。从代谢物的角度入手,赵世民的研究发现代谢物既受到细胞信号调控,又是细胞信号网络的调控因子,其失调通过改变细胞信号导致包括肿瘤、糖尿病、出生缺陷等疾病的发生。赵世民博士最新的研究方向是代谢物的感知与信号传导,他们发现了氨基酸的广谱感知和信号传导机制,并初步阐明了氨基酸信号失调与肿瘤、自闭症、糖尿病的发生之间的关系,为通过代谢调控干预相关疾病开辟了新思路。赵世民博士近年的研究成果发表在Science(3篇)、Cancer Cell、Cell Metabolism(2篇)、Molecular Cell(2篇)等期刊。

4. Title and unit

Speaker: Shi-Min Zhao, Ph.D.

Professor, Director

Obstetrics & Gynecology Institute,

Fudan University, Shanghai

5.Abstract:

We found that the signaling of intracellular amino acids can be sensed by their cognate tRNA synthetases and transmitted via lysine aminoacylation. This provided us opportunities to address questions such as why a given amino acid regulates specific cell signaling pathways and why certain amino acids deregulation is found in different diseases. For example, tyrosyl-tRNA synthetase (YARS) and phenoalanyl-tRNA synthetase (FARS) catalyzed aromatic amino acids modifications in proteins in insulin signaling pathway blunt insulin signaling, induce insulin resistance and type 2 diabetes. Inhibiting aromatic amino acids modifications rejuvenated insulin signals in cultured cells and reversed type 2 diabetes in mice; glutamyl-tRNA synthetase (EARS)-promoted glutamylation in  Methyl-CpG binding protein 2 (MeCP2) inactivates MeCP2 and resulted in the expression of a set a genes that are typically altered in  Rett syndrome and autism. The levels of glutamate, EARS and glutamylation were positively correlated to the onset of autism in children.  These results showed the importance of deregulated amino acids signals in the onset of human diseases and provide novel opportunities for the treatment of these diseases.

 

日期:9月13日(周四)16:00-17:00

地点:生物新馆143

 

 




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