10月29日水木清华生命科学讲座系列第93期 - 韩敬东
时间:2020-10-29 15:00-16:00
主讲人:韩敬东
主题:Trajectories and Heterogeneity of Development and Aging
地点:清华大学医学科学楼B323
Name: Jing-Dong Jackie Han (韩敬东)
Title: Professor,
Institute: Peking University, College of Interdisciplinary Studies, Center for Quantitative Biology
Email: jackie.han@pku.edu.cn
Research Interests
1) Systems biology of development and aging
2) Computational inference of regulatory networks
3) Computational algorithm development for image analysis, data integration and network analysis
Biography
Prof. Jing-Dong Jackie Han obtained Ph.D. degree from Albert Einstein College of Medicine. She had her postdoctoral training at The Rockefeller University and Dana-Farber Cancer Institute. In 2004, she became an investigator/professor at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. In 2010-2019, she was a director of the CAS-Max Planck Partner Institute for Computational Biology. In 2019, she became a tenured professor at Peking University. Her research focuses on the structure and dynamic inference of molecular networks,using a combination of large-scale experiments and computational analysis to explore the design principles of the networks and to find how the complex phenotypes, such as aging, cancer and stem cell development are regulated through molecular networks. She was awarded the NSFC Outstanding Young Scientist Award in 2006, and the Hundred Talent Plan Outstanding Achievement Award in 2009, selected as a Max Planck Follow in 2011 and a MaxNetAging Fellow in 2014, F1000 faculty in developmental biology in 2016.
Synopsis
Heterogeneity of Aging in Human Populations
Jing-Dong J. Han
1 Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing 100871, China
We have been interested in quantifying and predicting the temporal and spatial trajectories and inter-cell and inter-individual heterogeneity of development and aging. We developed reference-based methods to assess the speed of development and aging, through which we could infer the intrinsic timers and extrinsic influences (Chen et al., 2015; Sun et al., 2017). Spatial references can similarly define spatial trajectories during development (Chen et al., 2017; Huang et al., 2015; Peng et al., 2016; Peng et al., 2019)