北京大学生命科学学院2011学年秋季学期系列学术讲座之十二
Heart Regeneration
报告人: Kenneth Poss
Associate Professor, Department of Cell Biology, Duke University
Early Career Scientist, Howard Hughes Medical Institute.
时间: 2011年12月16日(周五),13:00-14:30 pm。
地点: 北京大学生命科学学院一楼邓祐才报告厅。
报告人简介:
科研经历:
1993-1997 Graduate Student, Laboratory of Susumu Tonegawa, Department of Biology,
Massachusetts Institute of Technology.
1998-2000 Postdoctoral Fellow, Laboratory of Mark Keating, Department of Human Genetics,
University of Utah.
2000-2003 Postdoctoral Fellow, Laboratory of Mark Keating, Department of Cardiology,
Children’s Hospital.
2003-2009 Assistant Professor, Department of Cell Biology, Duke University.
2009- Associate Professor (with tenure), Department of Cell Biology, Duke University.
2009- Early Career Scientist, Howard Hughes Medical Institute.
代表性论文:
1. Poss, K. D., Wilson, L. G., and Keating, M. T. Heart regeneration in zebrafish. (2002). Science 298, 2188-2190.
2. Lee, Y., Grill, S., Sanchez, A., Murphy-Ryan, M., and Poss, K. D. (2005). Fgf signaling instructs positiondependent growth rate during zebrafish fin regeneration. Development 132, 5173-5183.
3. Lepilina, A., Coon, A. N., Kikuchi, K., Holdway, J. E., Roberts, R. W., Burns, C. G., and Poss, K. D. (2006). A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 127, 607-619.
4. Wills, A. A., Holdway, J. E., Major, R. J., and Poss, K. D. (2008). Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish. Development 135, 183-192. 5. Wills, A.A., Kidd, A.R., Lepilina, A., and Poss, K. D. (2008). Fgfs control homeostatic regeneration in adult zebrafish fins. Development 135, 3063-3070. PMCID: 2748931
6. Yin, V., Thompson, J. M., Thummel, R., Hyde, D., Hammond, S., and Poss, K. D. (2008). Fgf-dependent depletion of microRNA-133 promotes zebrafish appendage regeneration. Genes and Development 22, 728-733. PMCID: 2275425
7. Lee, Y., Hami, D., De Val, S., Kagermeier-Schenk, B., Wills, A. A., Black, B. L., Weidinger, G., and Poss, K. D. (2009). Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. Developmental Biology 331, 270-280. PMCID: 2821826
8. Lee, Y., Nachtrab, G., Klinsawat, P. W., Hami, D., and Poss, K. D. (2010). Ras controls melanocyte expansion during zebrafish fin stripe regeneration. Disease Models and Mechanisms 3, 496-503. PMCID: 2929184.
9. Kikuchi, K., Holdway, J. E., Werdich, A. A., Anderson, R. M., Fang, Y., Egnaczyk, G. F., Evans T., MacRae, C. A., Stainier, D. Y. R., and Poss, K. D. (2010). Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes. Nature 464, 601-605. PMCID: 3040215
10. Yin, C., Kikuchi, K., Hochgreb, T., Poss, K. D., and Stainier, D. Y. R. (2010). Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. Developmental Cell 18, 973-984. PMCID: 2908152
11. Poss, K. D. (2010). Advances in understanding tissue regenerative capacity and mechanisms in animals. Nature Reviews Genetics 11, 710-722. PMCID: 3069856
12. Kikuchi, K., Holdway, J. E., Major, R. J., Blum, N., Dahn, R. D., Begemann, G., and Poss, K. D. (2011). Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Developmental Cell 20, 397-404. PMCID: 3071981
13. Kikuchi, K., Gupta, V., Wang, J., Holdway, J. E., Wills, A. A., Fang, Y., and Poss, K. D. (2011). tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Development 138, 2895-2902. PMCID: 3119303
14. Wang, J., Panáková, D., Kikuchi, K., Holdway, J. E., Gemberling, M., Burris, J. S., Singh, S. P., Dickson, A. L., Lin, Y. F., Sabeh, Werdich, A. A., Yelon, D., MacRae, C. A., and Poss, K. D. (2011). The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development 138, 3421-3430. PMCID: 3143562
15. Nachtrab, G., Czerwinski, M., and Poss, K. D. (2011). Sexually dimorphic fin regeneration in zebrafish controlled by androgen/GSK3 signaling. Current Biology 21, 1912-1917. PMCID in progress
联系人: 刘东(电话:62753189)。
欢迎各位老师和同学积极参加!