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清华大学生物论坛 讲座
发布时间:2012-12-05关键字:清华大学生物论坛

 

Charles Irwin WHITE, PhD.
Directeur de Recherche,
Centre National de Recherche Scientifique, France.
 
Degrees:
1977-1980     Honours (Genetics) Degree of Bachelor of Science, University of Adelaide, South Australia.
 
1982-1985     Ph.D. (DNA Repair in Yeast), Genetics Division, National Institute for Medical Research, M.R.C., London, U.K.
                     Supervisors: S.G. Sedgwick and R. Holliday F.R.S.
 
 2000            Habilitation à Diriger des Recherches, Université Blaise Pascal, Clermont Ferrand, France.
 
Topic : Roles and mechanisms of recombination in meiosis and mitiosis
 
Abstract
Working with Arabidopsis thaliana, we are studying the roles and mechanisms of genetic recombination - indispensable to the maintenance of genome integrity and an essential source of genetic diversity. Recombination acts to repair DNA damage and in particular, DNA double-strand breaks (DSB). In addition to arising by accident (replication, radiation, mutagens), DSB are naturally present at the ends of linear eukaryotic chromosomes (telomeres) and also produced in a programmed manner in order to induce recombination and genetic exchange (meiosis). DSB are efficiently repaired through multiple individual pathways of homologous or non-homologous recombination and although knowledge of recombination mechanisms has considerably advanced, the complex interrelationships and regulation of these pathways are far from being fully understood. A particularly striking example of the danger of inappropriate recombination is seen in the severe karyotypic and genomic instability in the presence of telomere dysfunction.
 
Current knowledge of roles and mechanisms of recombination in plants will be presented through discussion of our recent results on somatic recombination pathways, responses to telomere dysfunction and the differing requirements for proteins of the Rad51 family in pairing of meiotic centromeric regions and chromosome arms.
 
Venue: Room143, New Biology Building, THU
Time: Dec 7 (Friday), 2012; 16:00
Host: Prof. Yijun Qi




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