Stefan A. Muljo, Ph.D.
Tenure-Track Investigator, Integrative Immunobiology Unit NIAID, National Institutes of Health
Education:
1994 B.A., Biology Honors Program
Johns Hopkins University, School of Arts and Sciences
1995 M.H.S., Molecular Microbiology & Immunology
Johns Hopkins University, School of Public Health
2002 Ph.D., Molecular Biology and Genetics, Graduate Program in Immunology
Johns Hopkins University, School of Medicine
Employment:
2002 Visiting Postdoctoral Researcher
Dept. of Molecular and Cell Biology, University of California
2003-2008 Postdoctoral Research Fellow
CBR Institute for Biomedical Research, Harvard Medical School, Dept. of Pathology
2008-present Tenure-Track Investigator
LI, Integrative Immunobiology Unit, NIAID, National Institutes of Health
Topic: Roles of Lin28b and microRNAs in (re)programming lymphocyte differentiation
Abstract:
The Integrative Immunobiology Unit is generally enamored by the RNA world. Specifically, we aim to elucidate the roles of novel non-coding RNAs and RNA-binding proteins (RBPs) in the control of lymphocyte differentiation and function. One of our major goals is to decipher gene regulatory networks that orchestrate cell fate decisions in the hematopoietic and immune systems, since perturbations in their genetic programming underlie many diseases including cancer, immunodeficiency, autoimmunity, allergy and infectious diseases. For tractable model systems, we analyze B cell development and CD4+ T helper cell differentiation since much is already known about their core transcriptional programs and signaling pathways. However, relatively little is known about post-transcriptional control of gene expression and the roles of non-coding RNAs in these systems. Thus, we pay special attention to novel regulatory RNAs and RBPs that may play an important role in the immune system, and employ an integrative systems biology approach to reverse engineer the molecular logic of gene expression programming.
Venue: Room143, New Biology Building, THU
Time: Mar. 11 (Monday), 2013; 16:30
Host: Prof. Li Yu
