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6月18日 清华大学生物论坛
发布时间:2013-06-14关键字:

Jean T. GreenbergPh.D.

University of Chicago

Department of Molecular Genetics and Cell Biology

Member, Committee of Microbiology

Member, Committee of Genetics, Genomics and Systems Biology

Plant Cell Co-editor

 

Title: New insights, through systems and reductionist approaches, for how the plant pathogen Pseudomonas syringae suppresses host immunity

 

Professor Greenberg obtained a PhD in Biophysics at Harvard University. During my graduate workshe discovered a major mechanism of adaptation of E. coli bacteria to oxidative stress through the discovery of the SoxRS regulon. Her postodoctoral work with Fred Ausubel focused on isolating and characterizing Arabidopsis mutants with altered responses to pathogens, including mutants that are compromised for cell death control. Her own lab focuses on the discovery and characterization of novel signaling components important for plant defense, cell death control and bacterial virulence mechanisms. The current lecture will focus on effectors proteins that are secreted by microbes.  A decade has passed since her group published the first genome-wide molecular genetic and bioinformatic analysis to comprehensively identify effector proteins that are injected into host cells through a type III secretion apparatus. This analysis facilitated an explosion of efforts to identify secreted/injected proteins and discern their functions in modulating host functions in both pathogens and symbionts. In this talk, she will discuss recent progress in dissecting effector functions and sites of action. An important advance is the observation that effectors can suppress immunity by targeting several members of multiprotein complexes that include or are targets of other effectors. 

 

Venue: Room143, New Biology Building, THU

Time: June 18 (Tuesday), 2013; 16:30

Host: Prof. Yule Liu

 




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