生命科学论坛
3月3日 清华大学生物论坛-XiangZhang
发布时间：2015-03-02关键字：
The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells
XiangZhang PhD
Baylor College of Medicine
Abstract：Breast cancer bone micrometastases can remain asymptomatic for years before progressing into overt lesions. The biology of this process, including the microenvironment niche and supporting pathways, is unclear. We find that bone micrometastases predominantly reside in a niche that exhibits features of osteogenesis. Niche interactions are mediated by heterotypic adherens junctions (hAJs) involving cancer-derived E-cadherin and osteogenic N-cadherin, the disruption of which abolishes niche-conferred advantages. We elucidate that hAJ activates the mTOR pathway in cancer cells, which drives the progression from single cells to micrometastases. Human data set analyses support the roles of AJ and the mTOR pathway in bone colonization. Our study illuminates the initiation of bone colonization, and provides potential therapeutic targets to block progression toward osteolytic metastases
Time: Mar.03th.2015,16:00
Venue: New Biology Buliding,Room 143
Host: Prof.Qiaoran Xi
举办单位：生命科学联合中心
