Molecular Mechanisms of Metabolites Sensing and Signal Transduction
赵世民
复旦大学
简历:
赵世民,复旦大学附属妇产科医院、生命科学学院、生物医学研究院教授;国家重大科学研究计划(蛋白质)首席科学家;国家“生物治疗协同创新中心”前沿平台PI。
2000年在美国Purdue大学生化系获博士学位,后任职美国宝洁(P&G)科学家,2006年全职回国任职复旦大学,从事代谢物感知机理及代谢物感知失调的致病机理研究。先后发现了代谢酶的乙酰化调控机制,代谢物参与细胞信号通路调控以及氨基酸感知体系。在包括Science、Cancer Cell、Molecular Cell、Cell Metabolism等期刊发表SCI论文二十多篇,总引用超过2500次。主持包括973、基金委重点项目(2项)以及科技部重大国际合作项目等多个项目。
Abstract:
The interconversion of metabolites provides the bases of the exchange of materials between organisms and their surroundings, and the connections among different physiologies. We found that metabolites are sensed through different mechanisms and deregulated metabolites-sensing contribute to pathology of various diseases. Acetyl-CoA, an indicator of both energy and nutrients, is sensed by protein lysine acetylation that regulates homeostasis of metabolites including glucose. a-Ketoglutarate is sensed by a-Ketoglutarate-dependent dioxygenases family proteins. IDH1 mutations produced 2-hydroxyglutarate or FH and SDH mutations accumulated fumarate and succinate promotes tumorigenesis through either disrupting a-Ketoglutarate sensing that alters epigenetics or promoting hypersuccinylation that induces cancerous metabolism and apoptosis resistance. Amino acids are sensed by tRNA synthetases and their signals are transmitted via lysine aminoacylation. The revealing of metabolites sensing and signal transmitting mechanisms is providing us opportunities to identify novel drugable targets.
时间:2016年4月19日,16:00
地点:生物新馆143
主持:陈立功研究员
举办单位:生命科学联合中心