Immune signaling in metabolic adaptation of endurance exercise
Chih-Hao Lee, Professor
Harvard T.H Chan School of Public Health
Biography:
1989 B.S. (Chemical Engineering) National Tsing-Hua University, Taiwan, R.O.C
1999 Ph.D. (Pharmacology) University of Minnesota Minneapolis, MN
1999-2004 Postdoctor Howard Hughes Medical Institute, Salk Institute
2004-Present Harvard School of Public Health
Abstract：
Obesity and related metabolic disorders, as a result of over-nutrition and reduced physical activity, are common health issues in modern societies. Exercise, notably endurance training has been shown to increase metabolic fitness and improve symptoms of the metabolic syndrome. Endurance exercise is an energy-demanding process, which triggers a systemic metabolic response to provide energy supply to support exercise physiology. This includes a transition from glycolytic to oxidative metabolism in prolonged exercise. This metabolic reprogramming is met with specialized muscle fibers exhibiting distinct energy substrate preferences and performances. Although exercise-associated metabolic benefits have been well documented in humans and animal models, the underlying mechanisms remain unclear. Several factors have been suggested to mediate certain exercise-induced metabolic effects within muscle and between muscle and other metabolically active tissues. IL-6 is one of the “myokines” whose production is rapidly increased after exercise but its level at the resting state declines with endurance training. We have found that the Th2 cytokine IL-13 and type 2 innate lymphoid (ILC2) cells that produce IL-13 are induced in muscle of mice trained on a treadmill. Circulating IL-13 levels are also increased in humans with endurance exercise training. A potential role for IL-13 signaling in regulating muscle oxidative metabolism in endurance exercise and its relevance in metabolic health will be discussed.
Time: Tuesday, Sep. 20th, 2016, 16:30-17:30
Venue: New Biology Building, Room 143
Host: Suneng Fu, Ph.D., School of Life Sciences
举办单位：生命科学联合中心
