Histone monoaminylation: novel mechanisms of epigenetic plasticity
Fishberg Department of Neuroscience
Friedman Brain Institute
Icahn School of Medicine at Mount Sinai
New York, New York 10029, USA
Biography：Dr. Ian S. Maze received his B.S. degree in 2005 from The Ohio State University and PhD. in 2010 from Mount Sinai School of Medicine and did his postdoctoral training with Dr. C. David Allis at the Rockefeller University. In 2014, he joined the Departments of Neuroscience and Pharmacological Sciences Icahn School of Medicine at Mount Sinai, New York and began his own career. He is a member of Society for Neuroscience and The New York Academy of Sciences. He has been honored several awards including NARSAD Young Investigator Award (2014), Travel Award Recipient, American College of Neuropsychopharmacology (2015), , UPenn MINS Rising Star Award in Addiction Research (2018) etc. Up to now, Ian has published more than 40 papers, including Nat Neurosci, PNAS, Neuron, PLoS One, 1 article in revision (Nature), and his work has attracted over 4600 citations. Dr. Ian ’s research focuses on understanding the molecular mechanisms of neurological plasticity. They focus much of their attention on the role of chromatin modulatory processes in the regulation of activity-dependent transcription at the levels of molecular, biochemical and behavioral neurobiology, aiming to delineate epigenetic functions for neuronally enriched and cell-type specific histone modifications (e.g., monoaminylations) and associated binding complexes.
Abstract：Chemical modifications of histone proteins, along with the “writers,” “erasers” and “readers” of these modifications, are capable of mediating a diverse set of DNA-templated processes including gene transcription. Here, Dr. Ian will provide evidence for a new class of histone posttranslational modification (PTM), serotonylation of glutamine, which occurs at position 5 (Q5ser) on histone H3 in serotonin (5-hydroxytryptamine, 5-HT) producing organisms. His talk title is “Glutamine 5 serotonylation in histone H3 is a permissive modification that functions combinatorially with H3K4me3 to potentiate gene expression”.
Time: Mar. 13th, 2018 16:00-17：00
Venue: New Biology Building, Room 143
Host: Prof. Li Haitao
举办单位：生命科学联合中心
