NMR studies of proteins and nucleic acids in cell-like environment
(类细胞环境中蛋白质与核酸的核磁共振研究)
Time: Apr. 24th, 2018, 16:30
Venue: Medical Science Building, Room B416
Host: Prof. Yi Xue
举办单位：生命科学联合中心
Conggang Li PhD
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics
Wuhan Institute of Physics and Mathematics (WIPM)
Chinese Academy of Sciences (CAS)
Wuhan, China 430071
Biography：Dr. Conggang Li obtained his B.S. degree from Wuhan University in 1997, M.S. degree in 2000 from Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Ph.D. from Florida State University and National High Magnetic Laboratory, U.S.A in 2007; He did postdoctoral training at University of North Carolina at Chapel Hill. In 2011 he received 1000 Young Talent Project award and started independent research at Wuhan Institute of Physics and Mathematics.
Abstract：Whether the structure of proteins determined in isolated, purified form truly represents its native structure in cells remains a question. Here we show that nuclear magnetic resonance spectroscopy (NMR) with proper labeling is capable of providing high-resolution structure for proteins and nucleic acids in complex intracellular or the mimic cellular environment. We investigated several model proteins, and nucleic acids under crowded, confined environment and in living cells by NMR and the results show that cellular environment influence protein structure and functions, hence environmental effects have to be taken account into bio-macromolecular studies.
