实验室研究方向：

T cells play essential roles in immune response. We are studying T cells with two directions:

1. Functional genomics in primary T cells

We are applying genome-wide CRISPR/Cas9 screen in primary T cell in vivo to answer fundamental questions in T cell biology, including development, activation, proliferation and differentiation, as well as T cell fitness (e.g. exhaustion) in tumor microenvironment.  Identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. Mechanisms of metabolic regulation of T cells

Metabolic reprogramming is a hallmark of T cell activation, but how metabolic pathways regulate T cell function remains poorly understood. We are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation T cell, and try to target metabolism to treat immune-related diseases.

近期代表性成果如下，

1. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437. 

2. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science, 2016 Oct 28; 354(6311): 481-484. *equal contribution. 

Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”. 

Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”.

Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.

3. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33. 

Highlighted in Nat Rev Mol Cell Biol, 2014; 15: 701, “A RAG dissociation inhibitor”.

博士后 招聘1-2名： 

应聘条件：具有免疫学、分子和细胞生物学相关专业博士学位，获得博士学位1年以内；近期以第一作者身份在国际知名学术期刊发表研究论文，符合清华大学博士后入站标准；热爱科研工作，责任心强，具备团队合作精神；具备较好的英语沟通、阅读和写作能力。

岗位待遇：在清华大学校定博士后工资待遇基础上，根据工作经验和能力可以享受具有国际竞争力的年薪式津贴。符合条件者，支持申请国家“博新计划”、清华“水木学者”、以及生命科学联合中心博士后奖学金支持计划。

申请方式：将简历（包括学历和论文发表情况）、研究自述（研究兴趣、成果以及未来职业规划）、及2-3名推荐人的联系方式发至：pengmin@tsinghua.edu.cn；主题标明“姓名+应聘博士后“。

[下载]