实验室研究方向：

T cells play essential roles in immune response. We are studying T cells with two directions:

1. Functional genomics in primary T cells

We are applying genome-wide CRISPR/Cas9 screen in primary T cell in vivo to answer fundamental questions in T cell biology, including development, activation, proliferation and differentiation, as well as T cell fitness (e.g. exhaustion) in tumor microenvironment.  Identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. Mechanisms of metabolic regulation of T cells

Metabolic reprogramming is a hallmark of T cell activation, but how metabolic pathways regulate T cell function remains poorly understood. We are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation T cell, and try to target metabolism to treat immune-related diseases.

博士后招聘

CAR-T肿瘤治疗方向和T细胞代谢调控方向各1名： 

应聘条件：具有免疫学、分子和细胞生物学相关专业博士学位，获得博士学位1年以内；近期以第一作者身份在国际知名学术期刊发表研究论文，符合清华大学博士后入站标准；热爱科研工作，责任心强，具备团队合作精神；具备较好的英语沟通、阅读和写作能力。

岗位待遇：岗位待遇按照清华大学相关规定执行。课题组将根据工作情况提供一定生活补助和绩效奖励。另外，根据本单位相关规定，博士后以第一作者、清华大学为第一单位发表高水平学术期刊可获得有非常有竞争力的绩效奖励（http://postdoctor.tsinghua.edu.cn/）；支持条件优秀者申请国家“博新计划”、清华大学“水木学者”计划（http://postdoctor.tsinghua.edu.cn/thu/index.htm）以及其他多种清华大学博士后支持计划。资助额度最高40万元，另有多项福利保障；清华大学提供可租住的博士后公寓（或较为优越的租房补贴）。

申请方式：将简历（包括学历和论文发表情况）、研究自述（研究兴趣、成果以及未来职业规划）、及2-3名推荐人的联系方式发至：pengmin@tsinghua.edu.cn；主题标明“姓名+应聘博士后“。

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