陈国强

研究方向:
生物合成新的高分子材料及其应用、微生物合成聚羟基脂肪酸酯PHA及其应用、代谢工程、合成生物学、生物发酵工程、生物材料。
本实验室主要是以微生物生产聚酯材料—聚羟基脂肪酸酯(PHA)及其应用为主要研究对象。PHA是微生物合成的热力学性能良好的、具有生物相容性和生物降解性的材料。经过20多年的研究开发，PHA已经被发展成为一个包括微生物发酵、，环保材料、医用材料、生物燃料、特种材料、精细化工、食品和医药等的产业链。并在国内外实现了产业化。目前我国在PHA的学术研究和产业化处于国际领先水平。

代表性科研论文：
1. Gao X, Chen JC, Wu Q and Chen GQ. Polyhydroxyalkanoates as a source of chemicals, polymers and biofuels. CURRENT OPINIONS ON BIOTECHNOLOGY doi:10.1016/j.copbio.2011.06.005
2. Liu Q, Luo G, Zhou XR and Chen GQ. Biosynthesis of Poly(3-hydroxydecanoate) and 3-Hydroxydodecanoate Dominating Polyhydroxyalkanoates by -Oxidation Pathway Inhibited Pseudomonas putida. METABOLIC ENGINEERING 13(1): 11-17, 2011
3. Peng SW, Guo XY, Shang GG, Li J, Xu XY, You ML, Li P, Chen GQ. An Assessment of the Risks of Carcinogenicity Associated with Polyhydroxyalkanoates through an Analysis of DNA Aneuploid and Telomerase Activity. BIOMATERIALS 32(10): 2546-2555, 2011
4. Li ZJ, Shi ZY, Jian J, Guo YY, Wu Q and Chen GQ. Production of Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from Unrelated Carbon Sources by Metabolically Engineered Escherichia coli. METABOLIC ENGINEERING 12(4): 352-359, 2010
5. Chen GQ. A Polyhydroxyalkanoates Based Bio- and Materials Industry. CHEMICAL SOCIETY REVIEWS 38 (8): 2434–2446, 2009
6. Zhang XJ, Luo RC, Wang Z, Deng Y and Chen GQ. Applications of (R)-3-hydroxyalkanoate Methyl Esters Derived from Microbial Polyhydroxyalkanoates as Novel Biofuel. BIOMACROMOLECULES 10: 707–711, 2009
7. Zou XH, Li HM, Wang S, Leski M, Yao YC, Yang XD, Huang QJ and Chen GQ. The Effect of 3-Hydroxybutyrate Methyl Ester on Learning and Memory in Mice. BIOMATERIALS 30: 1532-1541, 2009
8. Chen GQ and Wu Q. Polyhydroxyalkanoates as Tissue Engineering Materials. BIOMATERIALS 26(33): 6565-6578, 2005