吴嘉炜
研究方向 :
生物大分子的结构生物化学研究：
1. 糖尿病、肥胖症等疾病中关键蛋白的结构和功能研究
2. Wnt信号转导中骨架蛋白Axin及其相互作用蛋白的研究
3. MAPK信号通路中激酶和磷酸酶活力调控的分子机制
4. TGF-b信号通路中Smad蛋白的泛素化降解机制
代表性科研论文 :
1.Chen L, Wang J, Zhang YY, Yan SF, Neumann D, Schlattner U, Wang ZX, Wu JW*. AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nat Struct Mol Biol. 19(7):716-718, 2012.
2.Hao GF, Wang F, Li H, Zhu XL, Yang WC, Huang LS, Wu JW*, Berry EA, Yang GF*. Computational Discovery of picomolar Qo site inhibitors of cytochrome bc1 complex. J Am Chem Soc. 34(27):11168-76, 2012.
3.Gao X, Wei TD, Zhang N, Xie BB, Su HN, Zhang XY, Chen XL, Zhou BC, Wang ZX, Wu JW*, Zhang YZ*. Molecular insights into the terminal energy acceptor in cyanobacterial hycobilisome. Mol Microbiol. 85(5):907-15, 2012.
4.Xie T, Ren R, Zhang YY, Pang Y, Yan C, Gong X, He Y, Li W, Miao D, Hao Q, Deng H, Wang ZX, Wu JW*, Yan N*. Molecular mechanism for the inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by the protein phosphatase ABI1. J Biol Chem. 287(1):794-802, 2012.
5.Wang L, Liu YT, Hao R, Chen L, Chang ZJ, Wang HR, Wang ZX, Wu JW*. (2011) Molecular mechanism of the negative regulation of Smad1/5 by CHIP. [Epub ahead of print]
6.Liu YT, Dan QJ, Wang J, Feng Y, Chen L, Liang J, Li Q, Lin SC, Wang ZX, Wu JW*. (2011) Molecular basis of Wnt activation via the DIX-domain protein Ccd1. J Biol Chem. 286(10):8597-608.
7.Gao X, Wang J, Yu DQ, Bian F, Xie BB, Chen XL, Zhou BC, Lai LH, Wang ZX, Wu JW*, Zhang YZ*. (2010) Structural basis for the autoprocessing of zinc metalloproteases in the thermolysin family. Proc Natl Acad Sci U S A. 107(41):17569-74.
8.Zhao PL, Wang L, Zhu XL, Huang X, Zhan CG*, Wu JW*, Yang GF*. (2010) Subnanomolar inhibitor of cytochrome bc(1) complex designed by optimizing interaction with conformationally flexible residues. J Am Chem Soc. 132(1):185-94
9.Chen L, Jiao ZH, Zheng LS, Zhang YY, Xie ST, Wang ZX, Wu JW*. (2009) Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature. 459(7250):1146-9.