陈晔光

 

电话：86-10-62784794
邮箱：ygchen(at)mail(dot)tsinghua(dot)edu(dot)cn

研究方向 :
细胞信号转导：利用膜生物学、分子生物学、生物化学、细胞生物学和发育生物学等多学科技术手段研究TGF-β和Wnt信号的调控以及它们在胚胎发育、干细胞自我更新和分化、肿瘤形成和组织纤维化中的作用。

代表性科研论文 :

1. Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed J, Liao FF, Chen YG#, Xu H#  2012  Appoptosin is a novel proapoptotic protein and mediates cell death in neurodegeneration. Journal of Neuroscience, 32(44):155565-155576. .

2. Li, Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG#.  2012  BMP4 Signaling Acts via Dual Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells. Cell Stem Cell, 10:171-182.

3. Zhao B, Wang Q, Du J, Luo S, Xia J, Chen YG#  2012  PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Cell Research, 22(10):1467-1478.

4. Shi Y, Ding Y, Lei YP, Yang XY, Xie GM, Wen J, Cai CQ, Li H, Chen Y, Zhang T, Wu BL, Jin L, Chen YG#, Wang HY#  2012  Identification of novel rare mutations of DACT1 in human neural tube defects. Human Mutation, 33(10):1450-1455.

5. Li Z and Chen YG#  2012  Fine-tune of intrinsic ERK activity by extrinsic BMP signaling in mouse embryonic stem cells. Protein Cell, 3(6):401-404. (Perspective).

6. Yan X#, Zhang JY, Sun QY, Polygena T., Wu XP, Jolinda A.and Chen YG#. 2012  p21-activated Kinase 2 (PAK2) Inhibits TGF-_ Signaling in Madin-Darby Canine Kidney (MDCK) Epithelial Cells by Interfering with the Receptor-Smad Interaction Journal of Biological Chemistry,  287(17):13705-13712.

7. Huang F, Chen YG#  2012  Regulation of TGF-beta Receptor Activity. Cell & Bioscience 2012, 2:9 (doi:10.1186/2045-3701-2-9) (Review) .

8. Chen YG# , Li, Z, Wang XF#.  2012  Where PI3K/Akt Meets Smads: The Crosstalk Determines Human Embryonic Stem Cell Fate. Cell Stem Cell, 10(3):231-232. (Preview).

9. Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X,Chen YG#, Jiang D#, Ning W# 2011 Fstl1 Is a BMP4 Signaling Antagonist in Controlling Mouse Lung Development.Proc Natl Acad Sci. USA, 108:7058-63.

10. Gao C, Cao W, Bao W, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG# 2010 Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nature Cell Biology, 12:781-790.

11. Fei F, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han JD#, Chen YG# 2010 Genome-wide Mapping of Smad Target Genes Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination. Genome Research, 20:36-44.

12. Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X#, Chen YG# 2009 Single molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization. Proc Natl Acad Sci. USA, 106:15679-15683.

13. Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG# 2008 MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.

14. Ma J, Wang Q, Fei T, Han JD, Chen YG# 2007 MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987-994.

15. Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG# 2007 Smad7 antagonizes TGF-β signaling in the nucleus by interfering with functional Smad-DNA complex formation. Molecular and Cellular Biology, 27:4488-4499.

16. Zhang L, Zhou H, Su Y, SunS, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG#, Meng A# 2004 ZebrafishDpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117.