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陈国强

陈国强

 

电子邮件:chengq(at)biomed(dot)tsinghua(dot)edu(dot)cn

电话:+86-10-62783844

 

研究方向:
生物合成新的高分子材料及其应用、微生物合成聚羟基脂肪酸酯PHA及其应用、代谢工程、合成生物学、生物发酵工程、生物材料。
本实验室主要是以微生物生产聚酯材料—聚羟基脂肪酸酯(PHA)及其应用为主要研究对象。PHA是微生物合成的热力学性能良好的、具有生物相容性和生物降解性的材料。经过20多年的研究开发,PHA已经被发展成为一个包括微生物发酵、,环保材料、医用材料、生物燃料、特种材料、精细化工、食品和医药等的产业链。并在国内外实现了产业化。目前我国在PHA的学术研究和产业化处于国际领先水平。

 

代表性科研论文:

1. Cai L, Yuan MQ, Li ZJ, Chen JC and Chen GQ. Genetic engineering of Ketogulonigenium vulgare DSM 4025 to enhance the production of 2-keto-L-gulonic acid. J Biotechnol 157: 320– 325, 2012

2. Peng Q, Zhang ZR, Gong T, Chen GQ, Sun X. A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles. Biomaterials 33: 1583-1588, 2012

3. Dong CL, Li SY, Wang Y, Dong Y Tang ZGJ and Chen GQ. The cytocompatability of polyhydroxyalkanoates coated with a fusion protein of PHA repressor protein (PhaR) and Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) polypeptide. Biomaterials 33: 2593-2599, 2012

4. Chen GQ and Patel M. Plastics Derived from Biological Sources: Present and Future - A Technical and an Environmental Review. Chemical Rev 112: 2082-2099, 2012

5. Tripathi L, Wu LP and Chen GQ. Microbial synthesis of diblock copolymer poly-3-hydroxybutyrate-block-poly-3-hydroxyhexanoate [P(3HB)-b-P(3HHx)] by a genome reduced Pseudomonas putida KT2442. Microbial Cell Factories 11:44, 2012

6. Meng DC, Shi ZY, Wu LP, Zhou Q, Wu Q, Chen JC and Chen GQ. Production and characterization of poly(3-hydroxypropionate-co-4-hydroxybutyrate) with fully controllable structures by recombinant Escherichia coli containing an engineered pathway. Metab Eng 14: 317-324, 2012

7. Zhou XY, Yuan XX, Shi ZY, Meng DC, Jiang WJ, Wu LP, Wu Q, Chen JC and Chen GQ. Hyperproduction of poly(4-hydroxybutyrate) from glucose by recombinant E. coli. Microbial Cell Factories 11:54, 2012

8. Wang RY, Shi ZY, Chen JC and Chen GQ. Cloning large gene clusters from E. coli using in vitro single-strand overlapping annealing. ACS Synthetic Biology 1: 291–295, 2012

9. Wang RY, Shi ZY, Chen JC, Wu Q and Chen GQ. Enhanced co-production of hydrogen and poly-(R)-3-hydroxybutyrate by recombinant PHB producing E. coli over-expressing hydrogenase 3 and acetyl-CoA synthetase. Metab Eng 14: 496–503, 2012

10. Chen GQ. New challenges and opportunities for industrial biotechnology. Microbial Cell Factories 11: 111, 2012

11. Gao X, Yuan XX, Shi ZY, Shen XW, Chen JC, Wu Q and Chen GQ. Production of copolyesters of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates by E. coli containing an optimized PHA synthase gene. Microbial Cell Factories 11:130, 2012

12. Gao X, Chen JC, Wu Q and Chen GQ. Polyhydroxyalkanoates as a source of chemicals, polymers and biofuels. CURRENT OPINIONS ON BIOTECHNOLOGY doi:10.1016/j.copbio.2011.06.005

13.  Liu Q, Luo G, Zhou XR and Chen GQ. Biosynthesis of Poly(3-hydroxydecanoate) and 3-Hydroxydodecanoate Dominating Polyhydroxyalkanoates by -Oxidation Pathway Inhibited Pseudomonas putida. METABOLIC ENGINEERING 13(1): 11-17, 2011

14.  Peng SW, Guo XY, Shang GG, Li J, Xu XY, You ML, Li P, Chen GQ. An Assessment of the Risks of Carcinogenicity Associated with Polyhydroxyalkanoates through an Analysis of DNA Aneuploid and Telomerase Activity. BIOMATERIALS 32(10): 2546-2555, 2011

15.  Li ZJ, Shi ZY, Jian J, Guo YY, Wu Q and Chen GQ. Production of Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from Unrelated Carbon Sources by Metabolically Engineered Escherichia coli. METABOLIC ENGINEERING 12(4): 352-359, 2010

16.  Chen GQ. A Polyhydroxyalkanoates Based Bio- and Materials Industry. CHEMICAL SOCIETY REVIEWS 38 (8): 2434–2446, 2009

17.  Zhang XJ, Luo RC, Wang Z, Deng Y and Chen GQ. Applications of (R)-3-hydroxyalkanoate Methyl Esters Derived from Microbial Polyhydroxyalkanoates as Novel Biofuel. BIOMACROMOLECULES 10: 707–711, 2009

18.  Zou XH, Li HM, Wang S, Leski M, Yao YC, Yang XD, Huang QJ and Chen GQ. The Effect of 3-Hydroxybutyrate Methyl Ester on Learning and Memory in Mice. BIOMATERIALS 30: 1532-1541, 2009

19.  Chen GQ and Wu Q. Polyhydroxyalkanoates as Tissue Engineering Materials. BIOMATERIALS 26(33): 6565-6578, 2005

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