生命科学联合中心

汤超

电子邮件: tangc(at)pku(dot)edu(dot)cn；

电话: +86-10-62759762；

实验室主页: http://cqb.pku.edu.cn/tanglab/

研究方向:

汤超实验室主要进行定量系统生物学方面的交叉学科研究。我们应用和发展定量方法和工具，有机地结合理论、计算和实验来提出和解决关键生物学问题，目的是发现生物世界中的基本定量规律及普适性原理。目前研究方向主要集中在细胞和调控网络层次，具体包括：细胞周期调控中的系统设计原理，细胞是怎么及如何做各种决定的；生物网络中的功能、拓扑与动力学的关系；发育及细胞分化的数学模型；信息论在生物系统中的应用；基于网络结构的复杂疾病机理等。

代表性科研论文:

1. Li F, Lu Y, Long T, Ouyang Q*, Tang C*, The yeast cell-cycle network is robustly designed, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101 (14), 4781, 2004.

2. Trusina A, Papa FR*, Tang C*, Benefits of translation attenuation in the unfolded protein response: A modelingapproach, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105, 20280, 2008.

3. Ma W, Trusina A, El-Samad H, Lim WA*, Tang C*, Defining network topology that can perform biochemicaladaptation, CELL, 138, 760, 2009.

4. Li Z, Ni M, Li J, Zhang Y, Ouyang Q*, Tang C*, Decision making of the p53 network: Death by integration, JOURNAL OF THEORETICAL BIOLOGY, 271, 205, 2011.
5. Chau AH, Walter JM, Gerardin J, Tang C*, Lim WA*. Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell 151(2): 320-332, 2012.
6. J. Shu, C. Wu, Y. T. Wu, Z. Li, S. D. Shao, W. H. Zhao, X. Tang, H. Yang, L. J. Shen, X. H. Zuo, W. F. Yang, Y. Shi, X. C. Chi, H. Q. Zhang, G. Gao, Y. M. Shu, K. H. Yuan, W. W. He, C. Tang*, Y. Zhao and H. K. Deng* (2013). Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers. Cell 153(5): 963-975.
7. Yang X, Jost A.P.T, Weiner OD*, Tang C*. A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast. Molecular Biology of the Cell 24(15): 2419-2430, 2013.
8. Yang X, Lau K-Y, Sevim V, Tang C*. Design Principles of the Yeast G1/S Switch. PLoS Biol 11(10): e1001673, 2013.
9. Lu D, Hsiao JY, Davey NE, Voorhis VAV, Foster SA, Tang C*, D. O. Morgan DO*. Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. The Journal of Cell Biology, 207(1): 23-29, 2014.
10. Liu X, Wang X, Yang X, Liu S, Jiang L, Qu Y, Hu L, Ouyang Q, Tang C*. Reliable cell cycle commitment in budding yeast is ensured by signal integration. eLife: e03977, 2015.