蒋争凡

 

电子邮件: jiangzf(at)pku(dot)edu(dot)cn；

电话: +86-10-62757923；

实验室主页: http://www.bio.pku.edu.cn/cell/jiangzflab/members.htm

 

研究方向：

蒋争凡博士的研究领域是天然免疫及其相关细胞信号转导，主要利用大规模、高通量克隆表达及功能筛选、规模化酵母双杂交和蛋白质分离-肽谱技术，筛选并研究重要蛋白在天然免疫中的功能及作用机制，揭示天然免疫失控导致各种疾病，包括过敏反应、自身免疫病、慢性炎症的可能原因。所关注的关键科学问题包括：1）细胞识别胞质内病原微生物，激活天然免疫的分子机制；2）泛素化参与抗病毒信号通路的机制；3）感染引发I型干扰素及其它重要细胞因子产生及分泌的机制；4）天然免疫系统关键信号转导分子与疾病的相互关系。

 

代表性科研论文:

1. Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z*, Activation of STAT6 by STING is Critical for Antiviral Innate Immunity. Cell, 147 (2): 436-446, 2011.

2. Zhou X, You F, Chen H, Jiang Z* , Poly(C)-binding protein 1 mediates house-keeping degradation of mitochondrial antiviral signaling (MAVS). Cell Research, 10.1038/cr.2011.184,  2011.

3. You FP, Sun H, Zhou X, Sun WX, Liang SM, Zhai ZH and Jiang ZF*, PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. NATURE IMMUNOLOGY, 10, 1300-1308, 2009.

4. Sun WX, Li Y, Chen L, Chen HH, You FP, Zhou X, Zhou Y, Zhai ZH, Chen DY, Jiang ZF*, ERIS, an ER IFN stimulator,activates innate immune signaling through dimerization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OFTHE UNITED STATES OF AMERICA, 106(21), 8653-8. 2009.

5. Xiao H, Qian W, Staschke K, Qian YC, Cui G, Deng L, Ehsani M, Wang XL, Qian YW, Chen ZJ, Gilmour R, Jiang ZF*, LiXX*, Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kB activation, THE JOURNAL OF BIOLOGICALCHEMISTRY, 283(21), 14654-64. 2008.

6. Jiang ZF, Georgel P, Li CL, Choe JW, Crozat K, Rutschmann S, Du X, Bigby T, Mudd S, Sovath SY, Wilson IA, Olson A,Beutler B*, Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(29), 10961-66, 2006.

7. Jiang ZF, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, BeutlerB*, CD14 is required for MyD88-independent LPS signaling, NATURE IMMUNOLOGY, 6(6), 565-70. 2005.