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祁海

 

祁海

 

电子邮件: qihai(at)mail(dot)tsinghua(dot)edu(dot)cn 

电话:+86-10-62796757

  

科研方向:

多细胞互作和细胞间信息传递是免疫系统正常工作的必要基础。生发中心反应是体液免疫记忆的重要源头,其正常组织结构和细胞互作都受到精细的动态调控。深入理解这些调控机制,是更加合理地设计预防或治疗性抗体疫苗的前提。我们通过遗传、生化、细胞生物学手段以及活细胞、活组织动态成像方法试图理解以下问题:(1)在生发中心反应中关键性细胞互作的分子调控机理;(2)这些细胞互作的定性及定量特点如何参与细胞命运选择;(3)生发中心及滤泡组织结构的时空动态演化特点及分子调控机制;(4) 以上3个层次的组织与调节机制如何保持免疫系统在产生有效应答的同时避免自身反应。

 

代表性科研论文:

1.    Dan Liu*, Heping Xu*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi#. T-B cell entanglements and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 2014 (Oct 15, Epub ahead of print, doi:10.1038/nature13803).

2.    Coco Chu, Yifeng Wang, Xu Zhang, Xinya Ni, Junxia Cao, Wan Xu, Zhongjun Dong, Pengfei Yuan, Wensheng Wei, Yuanwu Ma, Lianfeng Zhang, Longyan Wu, and Hai Qi#. SAP-regulated T cell-APC adhesion and ligation-dependent and -independent Ly108-CD3z interactions. Journal of Immunology, 193:3860-3871, 2014 (Sep 12, Epub ahead of print, doi:10.4049/jimmunol.1401660)

3.    Hai Qi#, Wolfgang Kastenmuller# and Ronald N Germain#. Spatio-temporal basis of innate and adaptive immunity in secondary lymphoid tissue. Annual Review of Cell and Developmental Biology, 2014 (Aug 8, Epub ahead of print, doi: 10.1146/annurev-cellbio-100913-013254)

4.    Hai Qi#, Dan Liu, Weiwei Ma, Yifeng Wang, Hu Yan. Bcl-6 controlled TFH polarization and memory: the known unknowns. Current Opinion in Immunology, 28:34-41, 2014

5.    Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, Chenguang Xu, Wanli Liu, Lianfeng Zhang, and Hai Qi#. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496:523-527, 2013.

6.    Hai Qi#. From SAP-less T cells to helpless B cells and back: dynamic T-B interactions in germinal center development. Immunological Reviews 247:24-35, 2012.

7.    Hai Qi*, Jennifer L. Cannons*, Frederick Klauschen, Pamela L. Schwartzberg, and Ronald N. Germain. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455:764-769, 2008.

8.    Hai Qi, Jackson G. Egen, Alex Y. C. Huang, and Ronald N. Germain. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312:1672-1676, 2006.

 

 

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