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杨雪瑞

  

 
 
电子邮件: yangxuerui@tsinghua.edu.cn
电话:+86-10-62783943
 
 
科研方向
利用交叉学科的优势,结合系统生物学,基因组学,生物信息学,遗传学,及分子与细胞生物学的方法,系统性地研究主要疾病,如癌症,在分子水平的基因调节通路与网络。同时,针对特定的重要基因及调节通路,开展深入的分子生物学研究,阐明其具体的作用机理,为疾病诊断及药物研发提供分子生物学基础。 
实验室有机地结合计算与实验的优势,并开展广泛的合作研究。目前的研究集中于转录后(post-transcription)及转译(translation)相关的调节机理及其在肿瘤发生中的作用。
   
 
代表性科研论文 
1.  Sumazin P*, Yang X*, Chiu HS*, Chung W, Iyer A, Llobet-Navas D, Silva J & Califano A. An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma, Cell, 147(2), 2011: 370-81. (*: co-first author. Featured cover article)
2.  Wang X, Nath A, Yang X, Portis A, Walton SP, and Chan C. Synergy analysis reveals association between insulin signaling and desmoplakin expression in palmitate treated HepG2 cells. PLoS ONE, 6(11), 2011: e28138.
3.  Yang X, Nath A, Opperman MJ and Chan C. The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells, Molecular Biology of the Cell, 21(19), 2010: 3449-58.
4.  Yang X, Zhou Y, Jin R and Chan C. Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization, Bioinformatics, 25(17), 2009: 2236-43.
5.  Yang X and Chan C. Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through Bcl-2, Cell Research, 19(4), 2009: 469-86.
6.  Wu M*, Yang X*, and Chan C. A dynamic analysis of IRS-PKR signaling in liver cells: a discrete modeling approach, PLoS ONE, 4(12), 2009: e8040. (*: co-first author)
7.  Yang X, Wang X, Wu M, Dalkic E, and Chan C. Construction of gene networks by synergy analysis of the genes related to palmitate-induced cytotoxicity, Methods in Bioengineering: Systems Analysis of Biological Networks, chapter 5, 2009: 75-93.
8.  Zhou Y, Li Z, Yang X, Zhang L, Srivastava S, Jin R and Chan C. Using knowledge driven matrix factorization to reconstruct modular gene regulatory network. Assn for the Adv. of Artificial Intelligence proceedings, 2008: 811-6.
9.  Li Z, Srivastava S, Yang X, and Chan C. A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells, BMC Systems Biology, 1, 2007: 21-35.
10. Srivastava S, Li Z, Yang X, Yedwabnick M, Shaw S, and Chan C. Identification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity in hepatoma cells, BMC Genomics, 8(1), 2007: 364-75.
11. Li Z, Srivastava S, Mittal S, Yang X, Sheng L, and Chan C. A Three Stage Integrative Pathway Search (TIPS©) framework to identify toxicity relevant genes and pathways, BMC Bioinformatics, 8, 2007: 202-18.

 

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