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李程

  

李程

 

电子邮件: lch3000(at)gmail(dot)com;

电话: 

实验室主页: http://www.chenglilab.net

 

研究方向:

实验室主要研究兴趣为:癌症基因组学高通量测序数据的产生、建模、实验验证,目的是寻找个体化癌症医疗中新的致病和治疗机制,以及预测个体化用药效果的统计建模。代表研究项目包括底层数据分析,如使用高通量测序技术,精确地找出癌症样本中的发生的各种变异;整合性数据分析,如拷贝数、基因表达、小RNA 等癌症变异之间的调控关系、它们怎样帮助理解病理和预测治疗效果。

 

代表性科研论文:

1. Samur MK, Yan Z, Wang X, Cao Q, Munshi NC, Li C*, Shah PK*. canEvolve: A web portal for integrative oncogenomics. PLoS One. 2013;8(2):e56228.
2. Parkin B, Ouillette P, Li Y, Keller J, Lam C, Roulston D, Li C, Shedden K, Malek SN. Clonal evolution and devolution following chemotherapy in adult acute myelogenous leukemia. Blood. 2013. 121(2):369-77.
3. Yan Z, Shah PK, Amin SB, Samur MK, Huang N, Wang X, Misra V, Ji H, Gabuzda D, Li C*. Integrative analysis of gene and miRNA expression profiles with transcription factor-miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Res. 2012. 40(17):e135.
4. Huang N, Shah PK*, Li C*. Lessons from a decade of integrating cancer copy number alterations with gene expression profiles. Briefings in Bioinformatics. 2012; 13(3):305-16.
5. Cao Q, Zhou M, Wang X, Meyer CA, Zhang Y, Chen Z, Li C*, Liu XS*. CaSNP: a database for interrogating copy number alterations of cancer genome from SNP array data. Nucleic Acids Res. 2011. 39(Database issue):D968-74.
6. Chen M, Wang K, Zhang L, Li C*, Yang Y*. The discovery of putative urine markers for the specific detection of prostate tumor by integrative mining of public genomic profiles. PLoS One. 2011;6(12):e28552.
7. Li C, Kim SW, Rai D, Bolla AR, Adhvaryu S, Kinney MC, Robetorye RS, Aguiar RC. Copy number abnormalities, MYC activity and the genetic fingerprint of normal B-cells mechanistically define the microRNA profile of DLBCL. Blood. 2009. 113(26):6681-90.
8. Avet-Loiseau H, Li C, Magrangeas F, Gouraud W, Charbonnel C, Harousseau JL, Attal M, Marit G, Mathiot C, Facon T, Moreau P, Anderson KC, Campion L, Munshi NC, Minvielle S. Prognostic Significance of Copy-Number Alterations in Multiple Myeloma. J Clin Oncol. 2009. 27(27):4585-90.
9. Li C*, Beroukhim R, Weir BA, Winckler W, Garraway LA, Sellers WR, Meyerson M. Major copy proportion analysis of tumor samples using SNP arrays. BMC Bioinformatics. 2008; 9:204.
10. Li C. Automating dChip: toward reproducible sharing of microarray data analysis. BMC Bioinformatics. 2008; 9:231.
11. Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA. Evolution of the aging brain transcriptome and synaptic regulation. PloS One. 2008; 3(10):e3329.
12. Johnson WE, Li C*, Rabinovic A. Adjusting batch effects in microarray expression data using Empirical Bayes methods. Biostatistics. 2007; 8(1): 118-127.
(* : Correspondence).

 

 

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