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栗占国

   

栗占国

 

电子邮件: li99(at) bjmu (dot) edu (dot)cn

电话: 010-88324172

实验室主页: www.bdfs.org.cn

 

研究方向:

(1)类风湿关节炎、红斑狼疮及干燥综合征致病抗原、免疫反应及负调控机制;
(2)风湿免疫病分子标志物筛选及早期诊断方法的建立;
(3)从新型炎症因子、免疫负调控,探讨风湿免疫病的新型免疫干预方法。

 

代表性科研论文:

 

1. He J, Tsai LM, Leong YA… Z. Li﹡. Circulating precursor CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity, 2013,39(4):770-781.
2. Fanlei Hu, Rong Mu, Jiaxin Zhu… Z. Li﹡. Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Ann Rheum Dis,2014, 73(5):928-936.
3. Guo, C., F. Hu, H. Yi, Z. Feng, C. Li, L. Shi, Y. Li, H. Liu, X. Yu, H. Wang, J. Li, Z. Li﹡and X. Y. Wang﹡. Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis. Ann Rheum Dis, 2016, 75(1): 278-285.
4. Du, Y., Y. Su, J. He, Y. Yang, Y. Shi, Y. Cui, C. Luo, X. Wu, X. Liu, F. Hu, X. Ma, L. Zheng, J. Zhang, X. Zuo, Y. Sheng, L. Wu, X. Zhang, J. Guo and Z. Li﹡. Impact of the leukocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus and Sjogren's syndrome. Ann Rheum Dis, 2014, 74(11), 2070-2075.
5. Wang T, Sun X, Zhao J, Zhang J, Zhu H, Li C, Gao N, Jia Y, Xu D, Huang FP, Li N, Lu L, Li ZG﹡. Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood. Ann Rheum Dis, 2015, 74 (6):1293-1301.
6. Li ZG﹡. A new look at rheumatology in China--opportunities and challenges. Nat Rev Rheumatol, 2015, 11 (5):313-317.
7. Du, Y., Y. Cui, X. Liu, F. Hu, Y. Yang, X. Wu, X. Ma, X. Zuo, Y. Sheng, J. Xu, P. Zhu, L. Sun, N. Hong, X. Zhang, J. Guo and Z. Li﹡. Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol, 2014, 66:822-830.
8. Sun J, Li R, Guo J… Z Li﹡. Superior molecularly altered influenza virus hemagglutinin peptide 308-317 inhibits collagen-induced arthritis by inducing CD4+ Treg cell expansion. Arthritis Rheumatol,2012, 64 (7): 2158-2168.
9. Hu F, Liu H, Xu L, Li Y, Liu X, Shi L, Su Y, Qiu X, Zhang X, Yang Y, Zhang J, Li Z﹡. Hypoxia-inducible factor-1alpha perpetuates synovial fibroblast interactions with T cells and B cells in rheumatoid arthritis. Eur J Immunol, 2015.(Epub ahead of print)
10. Xu, C., X. Wang, R. Mu… Z Li﹡. Societal costs of rheumatoid arthritis in China: a hospital-based cross-sectional study.Arthritis Care Res(Hoboken), 2014,66:523-531.
11. Zhang X, Zhang S, He J, Hu F, Liu H, Li J, Zhu J, Li Z﹡. Ultrasonographic evaluation of major salivary glands in primary sjogren's syndrome: Comparison of two scoring systems. Rheumatology (Oxford), 2015, 54 (9):1680-1687.
12. He J, Ding Y, Feng M… Z Li﹡. Characteristics of Sjögren's syndrome in rheumatoid arthritis. Rheumatology (Oxford), 2013, 52(6):1084-1089.
13. Li R, Sun J, Ren LM, Wang HY… Z Li﹡. Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing. Rheumatology (Oxford),2012, 51(4):721-729.

 

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