肖俊宇
肖俊宇
电子邮件: junyuxiao(at)pku(dot)edu(dot)cn；
电话: +86-10-62757054(办公室)；
研究方向:
实验室致力于研究分泌系统内重要蛋白、特别是分泌系统内新型激酶的结构与功能研究。激酶是细胞功能的关键调节因子。分泌蛋白也会被磷酸化，但分泌系统内的激酶直到近年才被发现鉴定。最新研究表明分泌系统内部存在着一系列新型激酶，包括Fam20家族成员，POMK等。它们磷酸化分泌蛋白、多糖分子而调节人体包括骨骼发育在内的多种生理过程。我实验室综合结构、生化等多种手段，研究这些重要蛋白的功能和调控机制。
代表性科研论文:
1. Liang, K., Li, N., Wang, X., Dai, J., Liu, P., Wang, C., Chen, X.W., Gao, N., Xiao, J.* (2018). Cryo-EM structure of human mitochondrial trifunctional protein. Proc Natl Acad Sci U S A 115:7039-7044.
2. Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M.J., Guo, X., Tagliabracci, V.S., Dixon, J.E., Xiao, J.* (2018). Structure and evolution of the Fam20 kinases. Nature Communications 9:1218.
3. Liu, Y., Bhowmick, T., Liu, Y., Gao, X., Mertens, H.D.T., Svergun, D.I., Xiao, J.*, Zhang, Y.*, Wang, J.H.*, Meijers, R*. (2018). Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC. Neuron. 97(6):1261-1267.
4. Du, S., Qu, L.J., Xiao, J.* (2018). Crystal structures of the extracellular domains of the CrRLK1L receptor-like kinases ANXUR1 and ANXUR2. Protein Sci. 27:886-892.
5. Sun, X., Li, Y., He, W., Ji, C., Xia, P., Wang, Y., Du, S., Li, H., Raikhel, N., Xiao, J.*, Guo, H.* (2017). Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nature Communications 8:15758.
6. Cui, J., Zhu, Q., Zhang, H., Cianfrocco, M.A., Leschziner, A.E., Dixon, J.E.*, Xiao, J.* (2017). Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. eLife 6, e23990.
7. Zhu, Q., Venzke, D., Walimbe, A.S., Anderson, M.E., Fu, Q., Kinch, L.N., Wang, W., Chen, X., Grishin, N.V., Huang, N., Yu, L., Dixon, J.E., Campbell, K.P.*, Xiao, J.* (2016). Structure of protein O-mannose kinase reveals a unique active site architecture. eLife 5, e22238.
8. Yu, K., Yu, Y., Tang, X., Chen, H., Xiao, J.*, Su, XD*. (2016). Transcriptome analyses of insect cells to facilitate baculovirus-insect expression. Protein Cell 7:373-82.