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孙前文

 

孙前文

电子邮件sunqianwen@biomed.tsinghua.edu.cn

  

本实验室研究方向:

我们的研究领域为植物基因转录调控和基因组结构,重点关注特殊染色质结构 R-loop的形成、稳定与解除的分子机理以及相应的生物学功能如R-loop如何影响基因转录、基因组构成以及稳定性等。

 

代表性科研论文(*通讯作者):

1.  Yang Z#, Hou Q#, Cheng L#, Xu W, Hong Y, Li S and Sun Q*. RNase H1 cooperates with DNA gyrases to restrict R-loops and maintain genome integrity in Arabidopsis chloroplast. The Plant Cell, 2017, in press (#contributed equally).

2.  Xu W, Xu H, Li K, Fan Y, Liu Y, Yang X* and Sun Q*. The R-loop is a common chromatin feature of the Arabidopsis genome. Nature Plants, 2017, in press.

3.  Shafiq S#, Chen C#*, Yang J, Cheng L, Ma F, Widemann E and Sun Q*. DNA Topoisomerase 1 prevents R-loops accumulation to modulate auxin-regulated rice root development. Mol Plant, 2017 Jun 5; 10(6):821-833 (#contributed equally).

4.  Shafiq S, Li J and Sun Q*. Functions of plants long non-coding RNAs. Invited review, Biochim Biophys Acta. 2016 Jan;1859(1):155-62. 

5.  Csorba T#, Questa JI#, Sun Q# and Dean C. Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization. Proc Natl Acad Sci USA. 2014. 111:16160-5, (#contributed equally).

6.  Wang ZW, Wu Z, Raitskin O, Sun Q and Dean C. Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor. Proc Natl Acad Sci USA. 2014. 111:7468-73.

7.  Marquardt S, Raitskin O, Wu Z, Liu F, Sun Q and Dean C. Functional Consequences of Splicing of the Antisense Transcript COOLAIR on FLC Transcription. Mol Cell. 2014. 54:156-65. 

8.  Sun Q, Csorba T, Skourti-Stathaki K, Proudfoot NJ and Dean C. R-Loop Stabilization Represses Antisense Transcription at the Arabidopsis FLC Locus. Science. 2013. 340:619-21.

9.  Qin FJ, Sun QW, Huang LM, Chen XS and Zhou DX. Rice SUVH histone methyltransferase genes display specific functions in chromatin modification and retrotransposon repression. Mol Plant. 2010. 3:773-82. 

10.  Sun Q and Zhou DX. Rice jmjC domain-containing gene JMJ706 encodes H3K9 demethylase required for floral organ development. Proc Natl Acad Sci USA. 2008. 105:13679-84.

11.  Huang L#, Sun Q#, Qin F, Li C, Zhao Y and Zhou DX. Down-regulation of a SILENT INFORMATION REGULATOR2-related histone deacetylase gene, OsSRT1, induces DNA fragmentation and cell death in rice. Plant Physiol. 2007. 144:1508-19. (#contributed equally).

 

 

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