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陈春来

 

陈春来

电子邮件:CChunlai@gmail.com

 

研究方向:

1)发展单分子荧光方法和技术;

2)核糖体在蛋白质合成过程中翻译和调控机制的研究;

3)CRISPR系列蛋白靶向和剪切机制的研究。

  

代表性科研论文:

1. Sijia Peng, Ruirui Sun, Wenjuan Wang, and Chunlai Chen (*), (2017) Single-Molecule Photoactivation FRET: A General and Easy-to-Implement Approach to Break the Concentration Barrier, Angew. Chem. Int. Ed, 56(24):6882-6885

2. Shan Sun, Lin Li, Fan Yang, Xiaojing Wang, Fenghui Fan, Mengyi Yang, Chunlai Chen, Xueming Li, Hong-Wei Wang, Sen-Fang Sui (*), (2017) Elongation factor G initiates translocation through a power stroke, Nature Communications, in press

3. Chunlai Chen, Xiaonan Cui, John F. Beausang, Haibo Zhang, Ian Farrell, Barry S. Cooperman (*), and Yale E. Goldman (*), (2016) Elongation factor G initiates translocation through a power stroke, PNAS, 113(27):7515-20

4. Wei Liu, Chunlai Chen, Darius Kavaliauskas, Charlotte R. Knudsen, Yale E. Goldman (*) and Barry S. Cooperman (*), (2015) EF-Tu dynamics during pre-translocation complex formation: EF-Tu·GDP exits the ribosome via two different pathways, Nucleic Acids Res., 43(19):9519-28

5. Chunlai Chen, Haibo Zhang, Steven L. Broitman, Michael Reiche, Ian Farrell, Barry S. Cooperman(*), and Yale E. Goldman(*), (2013) Dynamics of translation by single ribosomes through mRNA secondary structures, Nature Structural & Molecular Biology, 20, 582-588.

6. Chunlai Chen, Michael J. Greenberg, Joseph M. Laakso, E. Michael Ostap, Yale E. Goldman(*) and Henry Shuman(*), (2012) Kinetic schemes for post-synchronized single molecule dynamics, Biophysical Journal, 102, L23-L25

7. Chunlai Chen, Benjamin Stevens, Jaskiran Kaur, Zeev Smilansky, Barry S. Cooperman(*), and Yale E. Goldman(*), (2011) Allosteric vs. Spontaneous E-site tRNA Dissociation Early in Protein Synthesis, PNAS, 108, 16980-16985.

8. Chunlai Chen, Benjamin Stevens, Jaskiran Kaur, Diana Cabral, Hanqing Liu, Yuhong Wang, Haibo Zhang, Gabriel Rosenblum, Zeev Smilansky, Yale E. Goldman(*), and Barry S. Cooperman(*), (2011) Single Molecule Fluorescence Measurements of Ribosomal Translocation Dynamics. Molecular Cell, 42, 367-377.

 

 

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