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陈春来

 

陈春来

电子邮件:CChunlai@gmail.com

 

研究方向:

发展和利用单分子荧光手段以揭示核糖体及其辅助因子在翻译过程中的功能和机制。以单分子荧光共振能量转移和荧光相关光谱等技术为主,结合其它生物物理学和生物化学手段,通过直接观测核糖体及其辅助蛋白因子在蛋白质合成过程中的相互作用和构型变化等动态过程,阐释它们在翻译及其调控中的功能和相应机制。

 

代表性科研论文:

1. Chunlai Chen, Haibo Zhang, Steven L. Broitman, Michael Reiche, Ian Farrell, Barry S. Cooperman, and Yale E. Goldman, Dynamics of translation by single ribosomes through mRNA secondary structures, Nature Structural & Molecular Biology, 2013, 20, 582-588.

2. Gabriel Rosenblum, Chunlai Chen, Jaskiran Kaur, Xiaonan Cui, Haibo Zhang, Haruichi Asahara, Shaorong Chong, Zeev Smilansky, Yale E. Goldman, and Barry S. Cooperman, Quantifying Elongation Rhythm during Full-Length Protein Synthesis, Journal of the American Chemical Society, 2012, 135(30), 11322-11329.

3. Chunlai Chen, Michael J. Greenberg, Joseph M. Laakso, E. Michael Ostap, Yale E. Goldman and Henry Shuman, Kinetic schemes for post-synchronized single molecule dynamics, Biophysical Journal, 2012, 102, L23-L25.

4. Chunlai Chen, Benjamin Stevens, Jaskiran Kaur, Zeev Smilansky, Barry S. Cooperman, and Yale E. Goldman, Allosteric vs. Spontaneous E-site tRNA Dissociation Early in Protein Synthesis, Proceedings of the National Academy of Sciences, 2011, 108, 16980-16985.

5. Chunlai Chen, Benjamin Stevens, Jaskiran Kaur, Diana Cabral, Hanqing Liu, Yuhong Wang, Haibo Zhang, Gabriel Rosenblum, Zeev Smilansky, Yale E. Goldman, and Barry S. Cooperman, Single Molecule Fluorescence Measurements of Ribosomal Translocation Dynamics. Molecular Cell, 2011, 42, 367-377. 6. Hanqing Liu, Chunlai Chen, Haibo Zhang, Jaskiran Kaur, Yale E. Goldman, and Barry S. Cooperman, The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis, Proceedings of the National Academy of Sciences, 2011, 108, 16223-16228.

6. Hanqing Liu, Chunlai Chen, Haibo Zhang, Jaskiran Kaur, Yale E. Goldman, and Barry S. Cooperman, The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis, Proceedings of the National Academy of Sciences, 2011, 108, 16223-16228. 

 

 

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