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乔杰

   

乔杰

 

电子邮件:jie.qiao(at)pku(dot)edu(dot)cn;

电话:

实验室主页

 

办公室:北京市海淀区花园北路49号北京大学第三医院妇产科,100191

  

研究方向: 

生殖内分泌疾病防治新策略、多囊卵巢综合征流行病学与发病机制,配子发生与胚胎发育的遗传学与表观遗传学调控机理、胚胎植入前遗传学诊断、辅助生殖技术安全性评估与新方法的建立。

 

代表性科研论文: 

1.H.S.,Guo,P,Zhu,L.Y.,Yan,R.,Li,B.Q.,Hu,Y.,Lian,J.,Yan,X.L.,Ren,S.L.,Lin,J.S., Li,X.H.,Jin,X.D.,Shi,P.,Liu,X.Y.,Wang,W.,Wang,Y.,Wei,X.L.,Li,F.,Guo,X.L.,Wu,X.Y.,Fan,J.,Yong,L.,Wen,Sunney X.,Xie,F.C.,Tang*,J.,Qiao*. The DNA methylation landscape of human early embryos. Nature(2014)511, 606–610.
2.Jie Qiao*, Rong Li,Fertility preservation: challenges and opportunities, Lancet. 2014 Oct 4;384(9950):1246-7.
3.Hou, Y., Fan, W. Yan, L., Li, R., Lian, Y., Huang, J., Li, J., Xu, L., Tang, F.*, Xie, X.S*. and Qiao, J*. Genome analyses of single human oocytes. Cell(2013), 155,1492-506.
4.Zhang Y, Chen Q, Zhang H, Wang Q, Li R, Jin Y, Wang H, Ma T, Qiao J*, Duan E*. Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation,Cell Res. 2015 Jan;25(1):139-42.
5.Yan, L., Yang, M., Guo, H., Yang, L., Wu ,J., Li, R., Li, P., Lian, Y., Zheng, X., Yan, J., Huang, J., Li, M., Wu, X., Wen, L., Lao, K.,R.Q., LI*, Qiao, J*. and Tang F*. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol(2013), 20, 1131-9.
6.Wen L, Li X, Yan L, Tan Y, Li R, Zhao Y, Wang Y, Xie J, Zhang Y, Song C, Yu M, Liu X, Zhu P, Li X, Hou Y, Guo H, Wu X, He C*, Li R*, Tang F*, Qiao J*.Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain.Genome Biol(2014) Mar 4;15(3):R49.
7.Qiao, J., Wang, Z.B., Feng, H.L., Miao, Y.L., Wang, Q., Yu, Y., Wei, Y.C., Yan, J., Wang, W.H., Shen, W., Sun, S.C., Schatten, H. and Sun, Q.Y*. The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects. Mol Aspects Med(2014)38,54–85.
8.Qiao, J. and Feng, H.L. Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence. Hum Reprod Update (2011)17, 17-33.
9.Zhao, Y., Fu, L., Li, R., Wang, L.N., Yang, Y., Liu, N.N., Zhang, C.M., Wang, Y., Liu, P., Tu, B.B., Zhang, X. and Qiao, J*. Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: plasma metabolomics analysis. BMC Med(2012)10,153.
10.Zhao Y, Zhang C, Huang Y, Yu Y, Li R, Li M, Liu N, Liu P, Qiao J*. Up-Regulated Expression of WNT5a Increases Inflammation and Oxidative Stress via PI3K/AKT/NF-kappaB Signaling in the Granulosa Cells of PCOS Patients. J Clin Endocrinol Metab. 2015 Jan;100(1):201-11.

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