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王建斌


王建斌

 

电子邮件:accuquantbio@biomed.tsinghua.edu.cn

实验室介绍:http://accuquantbio.life.tsinghua.edu.cn/index.html

 

 

研究方向:

基因组学新技术的开发及其在生物医学领域的应用。我们的目标是以更精确的方式分析遗传多样性,从而研究其对不同生命过程的影响。为此,我们一方面综合运用微流、高通量测序等手段,开发单细胞分析、单倍体分析、高准度测序等基因组学技术;另一方面,利用这些技术研究遗传、发育、癌症、免疫等过程背后的遗传学特性以及相关疾病的发病机理。具体研究方向包括:罕见遗传病的病因学研究;胚胎发育过程中的细胞谱系追踪;癌症干细胞的分裂与分化;免疫系统多样性的遗传学基础等。

 

代表性科研论文:

1. Peter A Underhill, G David Poznik, Siiri Rootsi, Mari Järve, Alice A Lin, Jianbin Wang, Ben Passarelli, Jad Kanbar, Natalie M Myres, Roy J King, Julie Di Cristofaro, Hovhannes Sahakyan, Doron M Behar, Alena Kushniarevich, Jelena Šarac, Tena Šaric, Pavao Rudan, Ajai Kumar Pathak, Gyaneshwer Chaubey, Viola Grugni, Ornella Semino, Levon Yepiskoposyan, Ardeshir Bahmanimehr, Shirin Farjadian, Oleg Balanovsky, Elza K Khusnutdinova, Rene J Herrera, Jacques Chiaroni, Carlos D Bustamante, Stephen R Quake, Toomas Kivisild, and Richard Villems. The phylogenetic and geographic structure of Y-chromosome haplogroup R1a. Eur. J. Hum. Genet. 23, 124–131 (2015).

2. Jianbin Wang and Stephen R Quake. RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection. Proceedings of the National Academy of Sciences of the United States of America 111, 13157–13162 (2014).

3. Charles F A de Bourcy#, Iwijn De Vlaminck#, Jad N Kanbar#, Jianbin Wang, Charles Gawad, and Stephen R Quake. A Quantitative Comparison of Single-Cell Whole Genome Amplification Methods. PLoS ONE 9, e105585 (2014).

4. Jianbin Wang#, H Christina Fan#, Barry Behr, and Stephen R Quake. Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm. Cell 150, 402–412 (2012).

5. H Christina Fan#, Wei Gu#, Jianbin Wang, Yair J Blumenfeld, Yasser Y El-Sayed, and Stephen R Quake. Non-invasive prenatal measurement of the fetal genome. Nature 487, 320–324 (2012).

6. Piero Dalerba#, Tomer kalisky#, Debashis Sahoo#, Pradeep S Rajendran, Michael E Rothenberg, Anne A Leyrat, Sopheak Sim, Jennifer Okamoto, Darius M Johnston, Dalong Qian, Maider Zabala, Janet Bueno, Norma F Neff, Jianbin Wang, Andrew A Shelton, Brendan Visser, Shigeo Hisamori, Yohei Shimono, Marc van de Wetering, Hans Clevers, Michael F Clarke, and Stephen R Quake. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat. Biotechnol. 29, 1120–1127 (2011).

7. H Christina Fan, Jianbin Wang, Anastasia Potanina, and Stephen R Quake. Whole-genome molecular haplotyping of single cells. Nat. Biotechnol. 29, 51–57 (2011).

8. Jianbin Wang#, Ying Zhou#, Haiwei Qiu, Huang Huang, Changhong Sun, Jianzhong Xi, and Yanyi Huang. A chip-to-chip nanoliter microfluidic dispenser. Lab Chip 9, 1831–1835 (2009).

 

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