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潘俊敏

潘俊敏

 

电子邮件:panjunmin@tsinghua.edu.cn

电话:86-10-62797600(实验室)

 

研究方向:

肝脏中糖脂代谢信号调控的分子机制与代谢性疾病。综合运用分子生物学、细胞生物学以及组学等手段,细胞以及小鼠模型等,以肝脏作为研究的主要器官,从糖脂代谢信号调控的角度探索肥胖、糖尿病以及肿瘤的发病机制。

 

代表性科研论文:

1.    Liang Y, Meng D, Zhu B, and Pan, J*. 2016. Mechanism of ciliary disassembly. Cell Mol Life Sci, 73(9):1787-802 (invited review).

2.    Meng D and Pan J*. 2016. A NIMA-related kinase, CNK4, regulates ciliary stability and length. Mol Biol Cell, 27(5):838-47.

3.    Hu Z, Liang Y, He W, and Pan J*. 2015. Cilia disassembly with two distinct phases of regulation. Cell Reports, 10, 1803-1810.

4.    Hu J, Liang Y, Meng D, Wang L, and Pan J*. 2015. Microtubule Depolymerizing Kinesins in the Regulation of Assembly, Disassembly and Length of Cilia and Flagella. Int Rev Cell Mol Biol, 317, 241-265 (invited review).

5.    Liang Y, Pang Y, Wu W, Hu Z, Han X, Xu Y, Deng H, and Pan J*. 2014. FLA8/KIF3B phosphorylation regulates kinesin-II interaction with IFT-B to control IFT entry and turnaround. Dev Cell, 30, 585-597 (feature article).

6.    Pan J and Snell W*. 2014. Organelle size: a cilium length signal regulates IFT cargo loading. Curr Biol, 24, R875-78.

7.    Meng D, Cao M, Oda T, and Pan J*. 2014. The conserved ciliary protein Bug22 controls planar beating of Chlamydomonas flagella. J Cell Sci, 127, 281-287.

8.    Cao M, Meng D, Wang L, Bei S, Snell W*, and Pan J*. 2013. Activation loop phosphorylation of a protein kinase is a molecular marker of organelle size that dynamically reports flagellar length. Proc Natl Acad Sci USA, 110, 12337-42.

9.    Wang L, Piao J, Cao M, Tao Q, Huang J, Deng H, Mao T, and Pan J*. 2013. Flagellar regeneration requires cytoplasmic microtubule depolymerization and kinesin13. J Cell Sci, 126, 1531-1540 (Cover image and feature article).

10.  Pan J*, T Seeger-Nukpezah, EA Golemis*. 2013. The roles of the cilium in normal and abnormal cell cycles: emphsis on renal cystic pathologies. Cell Mol Life Sci, 70, 1849-1874.

11.  Pan J*, Naumann-Bausch B, Wang L, Specht M, Scholz M, Trompelt K, and M Hippler*. 2011. Protein phosphorylation is a key event of flagellar disassembly revealed by analysis of flagellar phosphoproteins during flagellar shortening in Chlamydomonas. J Prot Res, 10, 3830-3839.

12.  Luo M, Cao M, Kan Y, Li G, Snell W and Pan J*. 2011. Protein phosphosphorylation states of an auroa-like kinase marks the length of growing flagella. Curr Biol21586-591.

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