网站地图 加入收藏 中文 English
 
首页 中心概况 组织机构 研究队伍 科学研究 人才培养 交流合作 支撑服务 人才招聘 下载专区 联系我们
当前位置:首页 - 研究队伍
程功

程功

 

电子邮件:gongcheng@mail.tsinghua.edu.cn

电话:86-10-62788494(办公室)

 

研究方向:

蚊媒病毒性传染病的致病机制及宿主免疫保护机制。从分子层面阐明登革病毒、寨卡病毒、乙脑病毒等多种重要蚊媒病毒感染传播的分子机制,根据发现的靶点研发新型疫苗干预措施,为重要蚊媒病毒的防治提供生物学基础。

 

 

 

代表性科研论文 :

 

1. Liu Y, Liu JY, Du SY, Shan C, Nie KX, Zhang RD, Li XF, Zhang RL, Wang T, Qin CF, Wang PH, Shi PY #, Cheng G #. Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes. Nature. 545: 482-486 (# Corresponding Author)

 

2. Xiao XP, Yang LJ, Pang XJ, Zhang RD, Zhu YB, Wang PH, Gao GJ #, Cheng G #. (2017) A Mesh-Duox pathway regulates homeostasis in the insect gut. Nature Microbiology. 1: 17020 (# Corresponding Author)

 

3. Liu Y, Liu JY, Cheng G #. (2016) Vaccines and immunization strategies for dengue prevention. Emerging Microbes & Infections. 5: e77 (# Corresponsding Author)

 

4. Liu JY, Liu Y, Nie KX, Du SY, Qiu JJ, Pang XJ, Wang PH, Cheng G #. (2016) Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes. Nature Microbiology. 1: 16087 (# Corresponsding Author)

 

5. Pang XJ, Xiao XP, Liu Y, Zhang RD, Liu JY, Liu QY, Wang PH, Cheng G #. (2016) Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology. 1: 16023 (# Corresponsding Author)

 

6. Cheng G #, Liu Y, Wang PH, Xiao XP. (2016) Mosquito defense strategies against viral infection. Trends in Parasitology. 32:  177–186 (# Corresponsding Author)

 

7. Xiao XP, Zhang RD, Pang XJ, Liang GD, Wang PH, Cheng G #. (2015) A neuron-specific antiviral mechanism prevents lethal flaviviral infection of mosquitoes. PLoS Pathogens. 11: e1004848 (# Corresponsding Author) 

 

8. Xiao XP, Liu Y, Zhang XY, Wang J, Li ZF, Pang XJ, Wang PH, Cheng G #. (2014) Complement-related proteins control Flavivirus infection of Aedes aegypti by inducing antimicrobial peptides. PLoS Pathogens. 10: e1004027 (# Corresponsding Author) 

 

9. Liu Y, Zhang FC, Liu JY, Xiao XP, Zhang SY, Qin CF, Xiang Y, Wang P, Cheng G #. (2014) Transmission-blocking antibodies against mosquito C-type lectins for Dengue prevention. PLoS Pathogens. 10: e1003931 (# Corresponsding Author) 

 

10. Cheng G, Cox J, Wang PH, Krishnan MN, Dai JF, Qian F, Anderson JF, Fikrig E. (2010) A C-Type Lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile Virus infection of mosquitoes. Cell. 142, 714-725. 

 

版权所有 生命科学联合中心