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程功

程功

 

电子邮件:gongcheng@mail.tsinghua.edu.cn

电话:86-10-62788494(办公室)

 

研究方向:

蚊媒病毒性传染病的致病机制及宿主免疫保护机制。从分子层面阐明登革病毒、寨卡病毒、乙脑病毒等多种重要蚊媒病毒感染传播的分子机制,根据发现的靶点研发新型疫苗干预措施,为重要蚊媒病毒的防治提供生物学基础。

 

 

代表性科研论文 (# 通讯作者):

1.   Liu JY, Liu Y, Nie KX, Du SY, Qiu JJ, Pang XJ, Wang PH, Cheng G #. (2016) Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes. Nature Microbiology. 1: 16087

2.   Pang XJ, Xiao XP, Liu Y, Zhang RD, Liu JY, Liu QY, Wang PH, Cheng G #. (2016) Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology. 1: 16023.

3.   Cheng G #, Liu Y, Wang PH, Xiao XP. (2016) Mosquito defense strategies against viral infection. Trends in Parasitology. 32:  177–186.

4.   Xiao XP, Zhang RD, Pang XJ, Liang GD, Wang PH, Cheng G #. (2015) A neuron-specific antiviral mechanism prevents lethal flaviviral infection of mosquitoes.PLoS Pathogens. 11: e1004848.

5.   Xiao XP, Liu Y, Zhang XY, Wang J, Li ZF, Pang XJ, Wang PH, Cheng G #. (2014) Complement-related proteins control Flavivirus infection of Aedes aegypti by inducing antimicrobial peptides. PLoS Pathogens. 10: e1004027.

6.   Liu Y, Zhang FC, Liu JY, Xiao XP, Zhang SY, Qin CF, Xiang Y, Wang P, Cheng G #. (2014) Transmission-blocking antibodies against mosquito C-type lectins for Dengue prevention. PLoS Pathogens. 10: e1003931.

7.   Cheng G, Cox J, Wang PH, Krishnan MN, Dai JF, Qian F, Anderson JF, Fikrig E. (2010) A C-Type Lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile Virus infection of mosquitoes. Cell. 142: 714-725.

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