生命科学联合中心

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赵扬

电子邮件:yangzhao@pku.edu.cn

研究领域：细胞重编程和再生医疗

研究方向:

1. 细胞可塑性的分子基础及其再生医疗应用

2. 基于直接谱系重编程（转分化）的再生医疗新策略诱导心肌细胞原位再生

3. 组织器官纤维化及损伤修复中的细胞命运调控及重编程

代表性科研论文:

（#Co-first author *Correspondence）

1. Lin P, Bai Y, Nian X, Chi J, Chen T, Zhang J, Zhang W, Zhou B, Liu Y, Zhao Y*. Chemically induced revitalization of damaged hepatocytes for regenerative liver repair. iScience. 2023 Nov 22; 26(12):108532. doi: https://doi.org/10.1016/j.isci.2023.108532.

2. Tao Y, Yang Y, Yang Z, Wang L, Wang SQ, Zhao Y*. Robust small molecule-aided cardiac reprogramming systems selective to cardiac fibroblasts. iScience. 2023 Nov 14;26(12):108466. doi: 10.1016/j.isci.2023.108466.

3. Wu J, Zhao H, Tao Y, Yang C, Yang Y, Zhou B*, Zhao Y*. An improved factor combination for in vivo reprogramming of cardiac myofibroblast to cardiomyocyte-like cell with dual recombinase tracing. Circulation. 2023 Nov 21;148(21):1728-1731. doi: 10.1161/CIRCULATIONAHA.122.062810.

4. Yang X^#, Chen D^#, Sun Q^#, Wang Y, Xia Y, Yang J, Lin C, Dang X, Cen Z, Liang D, Wei R, Xu Z, Xi G, Xue G, Ye C, Wang LP, Zou P, Wang SQ, Rivera-Fuentes P, Püntener S, Chen Z, Liu Y*, Zhang J*, Zhao Y*. A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems. Cell Discovery. 2023 Jun 6;9(1):53. doi: 10.1038/s41421-023-00543-1.

5. Li J^#, Bai Y^#, Liu Y, Song Z, Yang Y, Zhao Y*. Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems. Cell Reports. 2023 May 24;42(6):112566. doi: 10.1016/j.celrep.2023.112566.

6. Li J, Chi J, Yang Y, Song Z, Yang Y, Zhou X, Liu Y*, Zhao Y*. PHDs-seq: a large-scale phenotypic screening method for drug discovery through parallel multi-readout quantification. Cell Regeneration. 2023 Jun 2;12(1):22. doi: 10.1186/s13619-023-00164-9.

7. Bai Y, Yang Z , Xu X , Ding W , Qi J , Liu F , Wang X , Zhou B , Zhang W , Zhuang X, Li G , Zhao Y* Direct chemical induction of hepatocyte-like cells with capacity for liver repopulation. Hepatology. 2023 May 1;77(5):1550-1565. doi: 10.1002/hep.32686.

8. Yang Z^#, Xu X^#, Gu C, Nielsen AV, Chen G, Guo F*, Tang C*, Zhao Y*. Chemical Pretreatment Activated a Plastic State Amenable to Direct Lineage Reprogramming. Front Cell Dev Biol. 2022 Mar 25;10:865038. doi: 10.3389/fcell.2022.865038.

9. Zhao H, Zhang Y, Xu X, Sun Q, Yang C, Wang H, Yang J, Yang Y, Yang X, Liu Y*, Zhao Y*. Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury. Front Cell Dev Biol. 2021 Feb 26;9:608367. doi: 10.3389/fcell.2021.608367.

10. Yang Z^#, Xu X^#, Gu C^#, Li J, Wu Q, Ye C, Nielsen AV, Mao L, Ye J, Bai K, Guo F*, Tang C*, Zhao Y*.Chemicals orchestrate reprogramming with hierarchical activation of mastertranscription factors primed by endogenous Sox17 activation. Commun Biol. 2020 Oct 30;3(1):629. doi: 10.1038/s42003-020-01346-w.

11. Ye J^#, Ge J^#, Zhang X, Cheng L, Zhang Z, He S, Wang Y, Lin H, Yang W, Liu J, Zhao Y*, Deng H*. Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds. Cell Res. 2016 Jan;26(1):34-45. doi: 10.1038/cr.2015.142.

12. Zhao Y*^#, Zhao T^#, Guan J^#, Zhang X^#, Fu Y^#, Ye J^#, Zhu J, Meng G, Ge J, Yang S, Cheng L, Du Y, Zhao C, Wang T, Su L, Yang W, Deng H*. A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming. Cell. 2015 Dec 17;163(7):1678-91. doi: 10.1016/j.cell.2015.11.017.

13. Li X^#, Zuo X^#, Jing J^#, Ma Y, Wang J, Liu D, Zhu J, Du X, Xiong L, Du Y, Xu J, Xiao X, Wang J, Chai Z*, Zhao Y*, Deng H*. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015 Aug 6;17(2):195-203. doi: 10.1016/j.stem.2015.06.003.

14. Hou P^#, Li Y^#, Zhang X^#, Liu C^#, Guan J^#, Li H^#, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y*, Deng H*. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013 Aug 9;341(6146):651-4. doi: 10.1126/science.1239278.

15. Shu J^#, Wu C^#, Wu Y^#, Li Z^#, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W, Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C*, Zhao Y, Deng H*. Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell. 2013 May 23;153(5):963-75. doi: 10.1016/j.cell.2013.05.001.

16. Zhao Y^#, Yin X^#, Qin H^#, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H*. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell. 2008 Nov 6;3(5):475-9. doi: 10.1016/j.stem.2008.10.002.

17. Cai J^#, Zhao Y^#, Liu Y^#, Ye F, Song Z, Qin H, Meng S, Chen Y, Zhou R, Song X, Guo Y, Ding M, Deng H*. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology. 2007 May;45(5):1229-39. doi: 10.1002/hep.21582.