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赵扬

  

赵扬

 

电子邮件:yangzhao(at)pku(dot)edu(dot)cn;

研究领域:细胞重编程和再生医疗

实验室主页:http://www.imm.pku.edu.cn/wzsy/kytd/22743.htm

 

科研经历:
赵扬研究员2003年毕业于北京大学生命科学学院,2009年于北京大学获细胞生物学博士学位。2010至2013年在北京大学从事博士后研究工作,2013年任北京大学医学部助理研究员,2016年任北京大学分子医学研究所研究员,博士生导师,细胞重编程和再生医疗研究室主任(PI)。

 

研究方向:

1. 细胞命运决定和体细胞重编程的分子机制研究
2. 细胞重编程新技术的开发和诱导再生的小分子药物开发
3. 心血管系统和代谢系统相关功能细胞(例如心肌细胞、肝脏细胞等)的原位诱导再生

 

 

代表性科研论文: 

(* Corresponding author;# Co-first author)

1. Ye J. #, Ge J. #, Zhang X. #, Cheng L., Zhang Z.Y., He S., Wang Y., Lin H., Yang W.F., Liu J.F., Zhao Y. *, Deng H.K.* Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds. Cell Research. 2016. 26(1):34-45

2. Zhao Y. *, #, Zhao T. #, Guan J.Y. #, Zhang X. #, Fu Y. #, Ye J.Q. #, Zhu J.L., Meng G.F., Ge J., Yang S.S., Cheng L., Du Y.Q., Zhao C.R., Wang T., Su L.L., Yang W.F., Deng H.K.* A XEN-like state bridges the cell fate transition of fibroblasts to pluripotency during chemical reprogramming. Cell. 2015. 17;163(7):1678-91.

3. Li X. #, Zuo X.H. #, Jing J.Z. #, Ma Y.T., Wang J.M., Liu D.F., Zhu J.L., Du X.M., Xiong L., Du Y.Y., Xu J., Xiao X., Wang J.L., Chai Z.*, Zhao, Y.*, Deng H.K.*. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015. 17(2): p. 195-203.

4. Fang, R.G. #, Liu. K. #, Zhao, Y. #, Li, H.B., Zhu, D.C., Du, Y.Y., Xiang, C.G., Li, X., Liu, H.S., Miao, Z.C., Zhang, X., Shi, Y., Yang, W.F., Xu, J. *, Deng, H.K.* Generation of Naive Induced Pluripotent Stem Cells from Rhesus Monkey Fibroblasts. Cell Stem Cell, 2014. 15(4): p. 488-496.

5. Hou, P.P.#, Li, Y.Q.#, Zhang, X. #, Liu, C. #, Guan, J.Y. #, Li, H.G. #, Zhao, T., Ye, J.Q., Yang, W.F., Liu, K., Ge, J., Xu, J., Zhang, Q., Zhao, Y.*, Deng, H.K.* Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds. Science, 2013. 341(6146): p. 651-654.

6. Shu, J. #, Wu, C. #, Wu, Y.T. #, Li, Z.Y. #, Shao, S.D., Zhao, W.H., Tang, X., Yang, H., Shen, L.J ., Zuo, X.H., Yang, W.F., Shi, Y., Chi, X.C., Zhang, H.Q., Gao, G., Shu, Y.M., Yuan, K.H ., He, W.W., Tang, C.*, Zhao, Y., Deng, H.K.* Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers. Cell, 2013. 153(5): p. 963-975.

7. Li, Y.Q. #, Zhang, Q.A. #, Yin, X.L., Yang, W.F., Du, Y.Y., Hou, P.P., Ge, J.A., Liu, C., Zhang, W.Q., Zhang, X., Wu, Y.T., Li, H.G., Liu, K., Wu, C., Song, Z.H., Zhao, Y.*, Shi, Y.*, Deng, H.K.* Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Research, 2011. 21(1): p. 196-204.

8. Zhao, Y. #, Yin, X.L. #, Qin, H. #, Zhu, F.F., Liu, H.S., Yang, W.F., Zhang, Q., Xiang, C.A., Hou, P.P., Song, Z.H., Liu, Y.X., Yong, J., Zhang, P.B., Cai, J., Liu, M., Li, H.G., Li, Y.Q., Qu, X.X., Cui, K., Zhang, W.Q., Xiang, T.T., Wu, Y.T., Zhao, Y.D., Liu, C., Yu, C., Yuan, K.H., Lou, J.N., Ding, M.X., Deng, H.K. Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation. Cell Stem Cell, 2008. 3(5): p. 475-479.

9. Cai, J. #, Zhao, Y. #, Liu, Y.X. #, Ye, F., Song, Z.H., Qin, H., Meng, S., Chen, Y.Z., Zhou, R.D., Song, X.J., Guo, Y.S., Ding, M.X., Deng, H.K. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology, 2007. 45(5): p. 1229-1239.

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