谷杨楠

 

邮箱：ygu@tsinghua.edu.cn

研究方向 : 

植物在与微生物长达几亿年的共存互作过程中演化出了极其复杂和精密的免疫系统。有别于具有专职免疫细胞的动物，植物的每一个细胞都可以启动免疫反应，甚至可以精确地调用和改变细胞的其他生理过程来实现多样化的免疫结果，是一个具有高度研究价值的系统。

 

本实验室致力于研究植物的免疫调控机制。我们利用分子，细胞，遗传，生化，生统，生物信息学等综合手段主攻此过程中免疫分子和信号是如何利用细胞内膜转运系统以及核质穿梭来启动，控制和终止抗病反应的。我们同时也关注细胞核膜上的大分子复合体（如核孔复合体）以及全新的跨膜蛋白对植物细胞免疫的调控作用。

代表性科研论文 :

1. Gu, Y., Zebell, S., Liang, Z., Wang, S., Kang, B. and Dong, X. (2016). Nuclear pore permeabilization is a convergent signaling event in effector-triggered immunity. Cell 166: 1526-1538. 

2. Liu, L., Sonbol, FM., Huot, B., Gu, Y., Withers, J., Mwimba, M., Yao, J., He, S.Y. and Dong, X. (2016). Salicylic acid receptors activate jasmonic acid signalling through a noncanonical pathway to promote effector-triggered immunity; Nature Communications 7: 13099.

3. Gu, Y. and Dong X. (2015). Stromules: signal conduits for plant immunity. Developmental Cell 34: 3-4.

4. Saleh, A., Withers, J., Mohan, R., Marques, J., Gu, Y., Yan, S., Zavaliev, R., Nomoto, M., Tada, Y. and Dong, X. (2015). Posttranslational modifications of the master transcriptional regulator NPR1 enable dynamic but tight control of plant immune responses; Cell Host-Microbe 18: 169-182.

5. Wang, S.*, Gu, Y.*, Zebell, S.*, Anderson, L.K., Wang, W., Mohan, R., and Dong, X. (2014). A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity. Cell Host-Microbe 16: 787-794. *Co-first authorship. 

6. Serrano, I.*, Gu, Y.*, Qi, D., Dubiella, U. and Innes, R.W. (2014). The Arabidopsis EDR1 protein kinase negatively regulates the ATL1 E3 ubiquitin ligase to suppress cell death. Plant Cell 26: 4532-4546. *Co-first authorship. 


7. Gu, Y. and Innes, R.W. (2012). The Keep On Going (KEG) protein of Arabidopsis regulates intracellular protein trafficking and is degraded during fungal infection. Plant Cell 24: 4717-4730. 

8. Gu, Y. and Innes, R.W. (2011). The Keep On Going (KEG) protein of Arabidopsis physically interacts with the Enhanced Disease Resistance 1 (EDR1) protein and recruits it to early endosomes; Plant Physiology 115: 1827-1838.