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杜亚楠

 

 

杜亚楠


电子邮件:duyanan@TSINGHUA.EDU.CN

电话:86-10-62781691(实验室)

实验室网站: http://dulab.med.tsinghua.edu.cn/


研究方向:


通过高度交叉和创新形成了微组织工程这一独具特色的研究方向。研究内容为应用微纳加工技术、生物材料和生物力学等手段构建精确可控、具有仿生结构和功能的“定制化”生理和病理3D微尺度组织,为再生医学以及药物筛选和病理研究提供新型平台技术、理论模型和解决方案。


代表性科研论文:

1.    Liu L, You Z, Yu H, Zhou L, Zhao H, Yan X, Li D, Wang B, Zhu L, Xu Y, Xia T, Shi Y, Huang C, Hou W, Du, Y*, ‘Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis’ Nature Materials 16(12):1252-1261(2017)

2.    Yan X, Zhou L, Wu Z, Wang X, Chen X, Yang F, Guo Y, Wu M, Chen Y, Li W, Wang J*, Du Y*. ‘High throughput scaffold-based 3D micro-tumor array for efficient drug screening and chemosensitivity testing’. Biomaterials. 2018 May doi: 10.1016/j.biomaterials.2018.05.020

3.    Fan X, Zhu L, Wang K, Wang B, Wu Y, Xie W, Huang C, Chan BP, Du Y* ‘Stiffness-Controlled Thermoresponsive Hydrogels for Cell Harvesting with Sustained Mechanical Memory’ Adv Healthc Mater. Mar;6(5) doi:10.1002/adhm.201601152. (2017)

4.    Qi C, Li Y, Badger P, Yu H, You Z, Yan X, Liu W, Shi Y, Xia T, Dong J, Huang C, Du Y*, ‘Pathology-targeted cell delivery via injectable micro-scaffold capsule mediated by endogenous TGaseBiomaterials 126:1-9 (2017)

5.    Zhu L, Fan X, Wang B, Liu L, Yan X, Zhou L, Zeng Y, Poznansky MC, Wang L, Chen H, Du Y*Biomechanically primed liver microtumor array as a high-throughput mechanopharmacological screening platform for stroma-reprogrammed combinatorial therapyBiomaterials 124:12-24 (2017)

6.    Wang J, Chen F, Liu L, Qi C, Wang B, Yan X, Huang C, Hou W, Zhang M, Chen Y*, Du Y* Engineering EMT using 3D Micro-scaffold to Promote Hepatic Functions for Drug Hepatotoxicity EvaluationBiomaterials 91:11-22 (2016)

7.    Zeng Y, Chen C, Liu W, Fu Q, Han Z, Li Y, Feng S, Li X, Qi C, Wu J, Wang D, Corbett C, Chan BP, Ruan D*, Du Y*.  Injectable Microcryogels Reinforced Alginate Encapsulation of Mesenchymal Stromal Cells for Leak-proof Delivery and Alleviation of Canine Disc Degeneration’ Biomaterials  59:53-65  (2015)

8.    Zhao H, Zhou L, Zhang Q, Zhou X, Zhang Y, Chen H, Du Y* Bi-content micro-collagen chip provides contractility-based biomechanical readout for phenotypic drug screening with expanded and profiled targetsLab Chip, 15(17):3481-94 (2015)

9.    Li Y, Liu W, Liu F, Zeng Y, Zuo S, Feng S, Qi C, Wang B, Khademhosseini A, Bai J, Du Y* ‘Primed 3D Injectable Micro-Niches Enabling Low-dosage Cell Therapy for Critical Limb Ischemia’ PNAS 111(37):13511-6 (2014)

10. Liu W, Li Y, Feng S, Ning J, Chen H, Feng X, Du Y*Magnetically Controllable 3D Microtissues based on Magnetic microcryogels’ Lab on Chip (cover) 4(15):2614-25 (2014)

11. Zhao S, Zhao H, Zhang X, Li Y, Du Y* ‘Off-the-shelf Microsponge Arrays for Facile and Efficient Construction of 3D Cellular Microenvironment for Versatile cell-based assays’ Lab on Chip 13(12):2350-8 (2013)

 

 

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