生命科学联合中心

尹航

邮箱：yin_hang@tsinghua.edu.cn

学科方向：化学生物学、新药研发

尹航教授，清华大学校学术委员会委员、Bioorganic & Medicinal Chemistry Letters主编、Journal of Extracellular Vesicle责任主编、Cell Chemical Biology编委、中国生物医药产业链创新与转化联盟常务理事及重大需求专委会主任委员、全国中药标准化技术委员会委员等。尹航教授先后入选中组部国家特聘专家、中国科协海智计划特聘专家、获得国家自然基金委杰出青年科学基金、北京市卓越青年科学家奖、吴阶平-保罗·杨森医学药学奖、中国药学会科学技术一等奖、美国化学学会大卫·罗伯特森杰出药物化学家奖等奖项。

实验室主页：

http://www.yinlab-tsinghua.cn/

近五年代表性科研论文(H-Index= 61, citations>20,000):

1. Su, C.; Cheng, T.; Huang, J.; Zhang, T.; *Yin, H. “4-Octyl Itaconate Restricts STING Activation by Blocking Its Palmitoylation”, Cell Rep. 2023, 42, e113040.

2. Jin, X.; Xia, T.; Luo, S.; Zhang, Y.; Xia, Y.; *Yin, H. “Exosomal Lipid PI4P Regulates Small Extracellular Vesicle Secretion by Modulating Intraluminal Vesicle Formation”, J. Extracell. Vesicles 2023, 12, 12319.

3. Liang, J.; *Yin, H. “STAM Transports STING Oligomers into Extracellular Vesicles Down-Regulating the Innate Immune Response”, J. Extracell. Vesicles 2023, 12, e12316.

4. *Yin, H.; Fan, C.; Huang, Y.; *Chen, G. “Innovative Chemistry Research Driven by Medicine”, Fundamental Res. 2023, 3, 479-480.

5. Zhang, L.; Wei, X.; Wang, Z.; Liu, P.; Hou, Y.; Xu, Y.; Su, H.; Koci, M. D.; *Yin, H; *Zhang, C. “NF-κB Activation Enhances STING Signaling by Altering Microtubule-Mediated STING Trafficking”, Cell Rep. 2023, 42, e112185.

6. Cell Derived Small Extracellular Vesicles”, Interdisciplinary Med. 2023, 1, e20220015.

7. Shi, S.; Yang, X.; Hou, Y.; Jin, X.; Guo, L.; Zhou, Y.; Zhang, C.; *Yin, H. “USP15 Promotes cGAS Activation through Deubiquitylation and Liquid Condensation”, Nucleic Acid Res. 2022, 50, 11093-11108.

8. Li, Y.; Pu, D.; Huang, J.; Zhang, Y.; *Yin, H. “Protein Phosphatase 1 Regulates Phosphorylation of Gasdermin D and Pyroptosis”, Chem. Comm. 2022, 58, 11965-11968.

9. Shi, S.; Yang, X.; Liu, Y.; Li, H.; Chu, H.; Li^.G.; *Yin, H. “ZDHHC18 Negatively Regulates cGAS-Mediated Innate Immunity Through Palmitoylation”, EMBO J. 2022, 41, e109272.

10. Yang, X.; Shi, S.; Shen, S.; Li, H.; Su, C.; *Yin, H. “MARCH8 Attenuates cGAS-Mediated Innate Immune Responses Through Ubiquitylation”, Sci. Signal. 2022, 15, eabk3067 ((highlighted in “This Week in Science” Science 2022, 376, 593).

11. Yang, Y.; Csakai, A.; Jiang, S.; Smith, C.; Tanji, H.; Huang, J.; Jones, T.; Sakaniwa, K; Broadwell, L.; Shi, C.; Soti, S.; Ohto, U.; Fang, Y.; Shen, S.; Deng, F.; Shimizu, T.; *Yin, H. “Tetrasubstituted Imidazoles as Incognito Toll-like Receptor 8 A(nta)gonists”, Nat. Commun. 2021, 12, 4351(featured in the Editor’s Highlights to showcase among the 50 best papers in Organic Chemistry and Chemical Biology).

12. Huang, J.; Yuan, Y.; Zhao, N.; Pu, D.; Tang, Q.; Zhang, S.; Luo, S.; Yang, X.; Wang, N.; Xiao, Y.; Zhang, T.; Liu. Z.; Sakata-Kato, Y.; Hirata, K.; *Jiang, X.; *Kato, N.; *Yan, N.; *Yin, H. “Orthosteric-Allosteric Dual Inhibitors of PfHT1 as Selective Anti-Malarial Agents”, Proc. Natl. Acad. Sci. U. S. A. 2021, 118, e2017749118.

13. Wang, J.; Shi, C.; Xu, Q.; *Yin, H. “SARS-CoV-2 Nucleocapsid Protein Undergoes Liquid-Liquid Phase Separation into Stress Granules through Its N-Terminal Intrinsically Disordered Region”, Cell Discov. 2021, 7, 5.

14. Zhang, Y.; Xiao, Y.; Sun, G.; Jin, X.; Guo, L.; Li, T.; *Yin, H. “Harnessing the Therapeutic Potential of Extracellular Vesicles for Cancer Treatment”, Semin. Cancer Biol. 2021, 74, 92-104.

15. Jiang, X.; Yuan, Y.; Huang, J.; Zhang, S.; Luo, S.; Wang, N.; Pu, D.; Zhao, N.; Tang, Q.; Hirata, K.; Yang, X.; Jiao, Y.; Sakata-Kato, Y.; Wu, J.; Yan, C.; Kato, N.; *Yin, H.; *Yan, N. “Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum”, Cell 2020, 183, 258-268.

16. Xu, Q.; Dai, C.; Kong, J.; Chen, H.; Feng, J.; Zhang, Y.; *Yin, H. “Immune Profiling Before Treatment is Predictive of TLR9-Induced Antitumor Efficacy”, Biomaterials 2020, 263, 120379.

17. Xiao, Y.; Driedonks, T.; Witwer, K.; Wang, Q.; *Yin, H. “How Does an RNA Selfie Work? EV-Associated RNA in Innate Immunity as Self or Danger”, J. Extracell. Vesicles 2020, 9, e1793515.

18. Wang, Y.; Zhang, S.; Li, H.; Wang, H.; Zhang, T.; Hutchinson, M.; *Yin, H.; *Wang, X. “Small Molecule Modulators of Toll-Like Receptors”, Acc. Chem. Res. 2020, 53, 1046-1055 (cover article).

19. Gao, M.; Huang, J.; Jiang, X.; Yuan, Y.; Luo, S.; Wang, N.; Pang, H.; Deng, D.; Yao, C.; Lin, Z.; Pu, D.; Liu, Z.; Hu, Z.; *Yin, H. “Regulation of Aerobic Glycolysis to Decelerate Tumor Proliferation by Small Molecule Inhibitors Targeting Glucose Transporters”, Protein Cell 2020, 11, 446-451.

20. Zhang, Y.; Jin, X.; Liang, J.; Guo, Y.; Sun, G.; Zeng, X.; *Yin, H. “Extracellular Vesicles Derived from ODN-Stimulated Macrophages Promote Their Cellular Uptake by the Transfer and Activation of Cdc42”, Sci. Adv. 2019, 5, eaav1564.

21. Hu, Z.; Tanji, H.; Jiang, S.; Zhang, S.; Koo, K.; Chan, J.; Sakaniwa, K.; Ohto, U.; Candia, A.; Shimizu, T.; *Yin, H. “Small Molecule TLR8 Antagonists via Structure-Based Rational Design”, Cell Chem. Biol. 2018, 25, 1286-1291 (cover article).

22. Bhattacharyya, S.; Wang, W.; Qin, W.; Cheng, K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.; Tamaki, Z.; *Yin, H.; *Varga, J. “TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skin and Lung”, JCI Insight 2018, 3, e98850 (featured in “News & Views” Nat. Rev. Rheumatol. 2018, 14, 564-566).

23. Zhang, S.; Hu, Z.; Tanji, H.; Jiang, S.; Das, N.; Li, J.; Sakaniwa, K.; Jin, J.; Bian, Y.; Ohto, U.; Shimizu, T.; *Yin, H. “Small Molecule Inhibition of TLR8 through Stabilization of Its Resting State”, Nat. Chem. Biol. 2018, 14, 58-64 (cover article; featured as C&EN “Latest News”).