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尹航

 

尹航

清华大学药学院教授、副院长

中组部国家特聘专家

清华大学药学技术中心主任

 

电子邮件:yin_hang@tsinghua.edu.cn

电话:+86-10-62787094

课题组网站:http://www.sps.tsinghua.edu.cn/yinlab/Index.html

研究趣:免疫物研、癌症筛查断、湿免疫疾病等

  尹航教授于1999年获得北京大学应用化学学士学位,2004年获得美国耶鲁大学化学专业博士学位,此后在美国宾夕法尼亚大学医学院从事博士后研究。加入清华大学之前于美国科罗拉多大学化学和生物化学系任终身教授。2018年起任清华大学药学院全职教授、副院长,药学技术中心主任。本团队在本领域一流期刊《科学》、《自然》、《科学》及《细胞》子刊,《美国国家科学院院刊》,《德国应用化学》,《美国化学学会志》等发表研究论文超过100 (H-Index38 总引用>6000) ;并多次被《自然》、《科学》、《美国国家科学院院刊》、美国化学会会刊《C&EN》等杂志作为科研亮点专题报道。科研成果已申请专利11项(授予美国、欧盟、日本等专利4项),并有多项专利成果已经商业化。尹航教授先后获得国家自然基金委杰出青年科学基金、美国化学学会大卫·W·罗伯特森杰出药物化学家奖、中美化学及化学生物学教授联合会杰出青年教授奖、美国国家科学基金会杰出青年教授奖、美国癌症研究学会格特魯德·B·埃利恩奖、美国癌症研究学会的SU2C创新研究奖、悉德尼·金梅尔学者奖、霍华德·休斯医学研究院合作创新奖、以及美国国家卫生研究院的 NIDA 青年化学家奖等多个奖项。

 

近期代表性科研论文:

1.       Zhang, S.; Hu, Z.; Tanji, H.; Jiang, S.; Das, N.; Li, J.; Sakaniwa, K.; Jin, J.; Bian, Y.; Ohto, U.; Shimizu, T.; *Yin, H. “Small Molecule Inhibition of TLR8 through Stabilization of Its Resting State”, Nat. Chem. Biol. 2018, 14, 58-64 (cover article; featured in C&EN “Latest News”).

2.       Hu, Z.; Tanji, H.; Jiang, S.; Zhang, S.; Koo, K.; Chan, J.; Sakaniwa, K.; Ohto, U.; Candia, A.; Shimizu, T.; *Yin, H. “Small Molecule TLR8 Antagonists via Structure-Based Rational Design”, Cell Chem. Biol. 2018, 25, 1286-1291(cover article).

3.       Bhattacharyya, S.; Wang, W.; Qin, W.; Cheng, K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.; Tamaki, Z.; *Yin, H.; *Varga, J. “TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skin and Lung”, JCI Insight 2018, 3, e98850 (featured in “News & Views” Nat. Rev. Rheumatol. 2018, 14, 564-566).

4.       Zhang, L.; Shi, L.; Soars, S. M.; Kamps, J.; *Yin, H. “Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Anti-Inflammatory and Anti-Cancer Properties”, J. Med. Chem. 2018, 61, 5881-5899.

5.       Zhang, L.; Dewan, V.; *Yin, H. “Discovery of Small Molecules as Multi-TLR Agonists with Proinflammatory and Anticancer Activities”, J. Med. Chem.  2017, 60, 5029-5044.

6.       Smith, C. E.; Soti, S.; Jones, T. A.; Nakagawa, A.; Xue, D.; *Yin, H. “NSAIDs are Caspase Inhibitors”, Cell Chem. Biol. 2017, 24, 281-292 (featured in “Concentrates” C&EN 2017, 95(10), 10; NIH Research Matters; The Sun; Daily Mail).

7.       Das, N.; Dewan, V.; Grace, P. M.; Gunn, R. J.; Tamura, R.; Tzarum, N.; Watkins, L. R.; Wilson, I. A.; *Yin, H. “HMGB-1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia”, Cell Rep. 2016, 17, 1128-1140.

8.       *Yin, H.; Flynn, A.D. “Drugging Membrane Protein Interactions”, Annu. Rev. Biomed. Eng. 2016, 18, 51-76.

9.       Wang, T.; de Jesus, A.; *Shi, Y.; *Yin, H.; “Pyridoxamine is a substrate of the energy-coupling factor transporter HmpT", Cell Discov. 2015, 1, 15014.

10.    Daniele, S. G.; Beraud, D.; Davenport, C.; Cheng, K.; *Yin, H.; *Maguire-Zeiss, K. A.; “Activation of MyD88-Dependent TLR1/2 Signaling by Misfolded α-Synuclein, a Protein Linked to Neurodegenerative Disorders”, Sci. Signal. 2015, 8, ra45 (highlighted in “This Week in Science” Science 2015, 348, 769; Podcast: Maguire-Zeiss, K. A.; Daniele, S. G.; Yin, H.; VanHook, A. M.; Sci. Signal. 2015, 8, pc12; feature story by the Xinhua News Agency).      

11.    Cheng, K.; Gao, M.; Godfroy, J. I. III; Brown, P. N.; Kastelowitz, N.; *Yin, H.; “Specific Activation of the TLR1-TLR2 Heterodimer by Small-molecule Agonists”, Sci. Adv. 2015, 1, e1400139 (featured in “Science & Technology” C&EN 2015, 93(15), 39-40).

12.    Smith, C. E.; Wang, X. H.; *Yin, H.; “Caspases Come Together Over LPS”, Trends Immunol. 2015, 36, 59-61.

13.    Yang, H.; Chen, Y. Z.; Zhang, Y.; Wang, X. H.; Zhao, X.; Godfroy, J. I.; Liang, Q.; Zhang, M.; Zhang, T.; Yuan, Q.; Royal, M. A.; Driscoll, M.; Xia, N. S.; Yin, H.; Xue, D. “A Lysine-Rich Motif in the Phosphatidylserine Receptor PSR-1 Mediates Recognition and Removal of Apoptotic Cells”, Nat. Commun. 2015, 6, 5717.

14.    Csakai, A.; Smith, C.; Davis, E.; Martinko, A.; Coulup, S.; *Yin, H. “Saccharin Derivatives as Inhibitors of Interferon-Mediated Inflammation”, J. Med. Chem. 2014, 57, 5348-5355 (cover article).

15.    Wang, X. H.; Grace, P. M.; Pham, M. N.; Cheng, K.; Strand, K. A.; Smith, C. E.; Li, J.; Watkins, L. R.; *Yin, H. “Rifampin Inhibits Toll-like Receptor 4 Signaling by Targeting Myeloid Differentiation Protein 2 and Attenuates Neuropathic Pain”, FASEB J. 2013, 27, 2713-2722.

16.    Wang, X. H.; Smith, C.; *Yin, H. “Targeting Toll-Like Receptors with Small Molecule Agents”, Chem. Soc. Rev. 2013, 42, 4859-4866 (cover article).

17.    Brown, P. N.; *Yin, H. “PNA-Based MicroRNA Inhibitors Elicit Anti-Inflammatory Effects in Microglia Cells”, Chem. Commun. 2013, 49, 4415-4417 (2013 Emerging Investigators issue).

18.    Morton, L. A.; Saludes, J. P.; Beninson, L.; Chapman, E. R.; Fleshner, M.; *Yin, H. “MARCKS-ED Peptide as a Membrane Curvature Sensor”, ACS Chem. Biol. 2013, 8, 218-225.

19.    Cheng, K.; Wang, X. H.; Zhang, S.; *Yin, H. “Discovery of Small-Molecules that Inhibit the Protein Complex of Toll-Like Receptor 1 and 2”, Angew. Chem. Int. Ed. 2012, 51, 12246-12249 (cover article; featured in “Science & Technology Concentrates” C&EN 2012, 90(35), 33).

20.    Saludes, J. P.; Morton, L. A.; Ghosh, N.; Beninson, L.; Chapman, E. R.; Fleshner, M.; *Yin, H. “Detection of Highly Curved Membrane Surfaces Using a Cyclic Peptide Derived from Synaptotagmin-I”, ACS Chem. Biol. 2012, 7, 1629-1635.

21.    Wang, X. H.; Loram, L. C.; Ramos, K.; de Jesus, A.; Thomas, J.; Cheng, K.; Reddy, A.; Somogyi, A. A.; Hutchinson, M. R.; Watkins, L. R.;  *Yin, H. “Morphine Activates Neuroinflammation in a Parallel Manner to Endotoxin”, Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 6325-6330 (highlighted in “Research Highlights This Week” Nature 2012, 484, 419; “This Week in PNAS”; Sci. Signal. Editors’ Choice; featured on the website of the Association of American Universities; recommended by the Faculty of 1000 website).

22.    Chavez, S. A.; Martinko, A. J.; Lau, C.; Pham, M. N.; Cheng, K.; Mollnes, T. E.; *Yin, H. “Development of β–Amino Alcohol Derivatives that Inhibit TLR4-Mediated Inflammatory Response as Potential Antiseptics”, J. Med. Chem. 2011, 54, 4659-4669 (headlined in Global Medical Discovery).

23.    Cheng, K.; Wang, X. H.; *Yin, H. “Small Molecule Inhibitors of the TLR3/dsRNA Complex”, J. Am. Chem. Soc. 2011, 133, 3764-3767.

24.    *Yin, H. “Exogenous Agents that Target Transmembrane Domains of Proteins”, Angew. Chem. Int. Ed. 2008, 47, 2744-2752 (cover article).

25.    Yin, H.; Slusky, J. S; Berger, B. W.; Walters, R. S.; Vilaire, G.; Litvinov, R. I.; Lear, J. D.; Caputo, G. A.; Bennett, J. S.; DeGrado, W. F. “Computational Design of Peptides that Target Transmembrane Helices”, Science 2007, 315, 1817-1822 (featured in “News of the Week” C&EN 2007, 85, 11; “News and Views” Nat. Biotech. 2007, 25, 646; and “Editors’ Choice” Sci. Signal. 2007, 2007, tw119).

 

 

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