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韩敬东

 

 

韩敬东

 

 

电话: +86-010-62757330

电子邮件: jackie.han@pku.edu.cn

实验室主页http://www.picb.ac.cn/hanlab/index.htm

 

研究方向:

 

实验室研究方向主要包括以下三个方面:(1)衰老的系统生物学研究、干细胞分化以及癌症的发生发展;(2)开发数据整合和网络分析的计算方法;(3)探求遗传网络中内在的安全稳定机制。运用数据挖掘、统计学方法和网络理论,首先提出合理的生物学假说或模型,然后利用分子生物学、细胞生物学和系统生物学的方法,对该生物学假说或模型进行证实、完善。

 

代表性科研论文:

 

1)      Guangdun Peng^*, Shengbao Suo^, Guizhong Cui^, Fang Yu^, Ran Wang, Jun Chen, Shirui Chen, Zhiwen Liu, Guoyu Chen, Yun Qian, Patrick P. L. Tam, Jing-Dong J. Han* and Naihe Jing*. Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature August, 2019. 

2)      Yaqiang Cao, Guoyu Chen, Gang Wu, Xiaoli Zhang, Joseph     McDermott, Xingwei Chen, Chi Xu, Quanlong Jiang, Zhaoxiong Chen,  Yingying Zeng, Daosheng Ai, Yi Huang and Jing-Dong J. Han*. Widespread roles of enhancer-like transposable elements in cell identity and long-range genomic interactions. Genome Research. 2018. 29(1):40-52

3)      Denghui Liu, Xinyi Wang, Dajian He, Chunli Sun, Xiechao He, Lanzhen Yan, Yizhou Li, Jing-Dong J. Han* and Ping Zheng*. Single cell RNA-sequencing reveals the existence of naïve and primed pluripotency in pre-implantation rhesus monkey embryos. Genome Research. 2018. 10(28):1481-1493

4)      Sun N, Yu X, Li F, Liu D, Suo S, Chen W, Chen S, Song L, Green CD,  McDermott J, Shen Q, Jing N and Han JJ*, Inference of differentiation time for single cell transcriptomes using cell population reference data, Nature Communications,2017Nov30 ;8(1):1856:1-12.doi:10.1038/s41467-017-01860-2

5)      Chen J, Suo S, Tam PP, Han JJ*, Peng G, Jing N*. Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nature Protocol, 2017 vol. 12 (3):566-580  

6)      Lei Hou, Dan Wang, Di Chen, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, and William B. Mair and Jing-Dong J. Han*. A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metabolism, 2016, 8;23(3):529-40

 

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