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时松海

时松海

 

电子邮件:shisonghai@mail.tsinghua.edu.cn

电话:+86-10-62793272(实验室)

 

研究方向:

大脑神经系统是如何组装的,以及如何调控动物的行为和认知一直是神经科学的研究热点和终极目标之一。我们运用神经生物学(如电生理和成像)、遗传学、分子、细胞和发育生物学等方法研究大脑的组装和运行机制,集中于活体神经干细胞的调控、神经细胞的产生迁移、神经环路的精准组装和运行、以及动物行为的神经基础,同时致力于与神经发育相关的重大疾病如小脑症和自闭症的致病机制研究。

 

代表性科研论文:

1.    Shao, W.*, Yang, J.*, He, M., Yu, X.-Y., Lee, C.H., Yang, Z., Joyner, A.L., Anderson, K. V., Zhang, J., Tsou, M.B., Shi, H., and Shi, S.-H. (2020) Centrosome Anchoring Regulates Progenitor Properties and Cortical Formation. (* Co-first author) Nature 580:106-112. (PMCID: PMC7138347)

2.    Ren, S.Q., Li, Z., Lin, S., Bergami, M., and Shi, S.-H. (2019) Precise Long-range Microcircuit-to-microcircuit Communication Connects the Frontal and Sensory Cortices in the Mammalian Brain. Neuron 104: 1-17. (PMCID: PMC6813886)

3.    Sultan, K.T., Liu, W.A., Li, Z.-L., Shen, Z., Li, Z., Zhang X.-J., Dean, O., Ma, J., and Shi, S.-H. (2018) Progressive Divisions of Multipotent Neural Progenitors Generate Late-born Chandelier Cells in the Neocortex. Nat. Commun. 9: 4595. (PMCID: PMC6214958)

4.    Zhang, X.-J., Li, Z., Han, Z., Sultan, K.T., Huang, K., and Shi, S.-H. (2017) Precise Inhibitory Microcircuit Assembly of Developmentally Related Neocortical Interneurons in Clusters. Nat. Commun. 8:16091. (PMCID: PMC5511369)

5.    Shi, W., Xianyu, A., Han, Z., Tang, X., Li, Z., Zhong, H., Mao, T., Huang, K., and Shi, S.-H. (2017) Ontogenetic Establishment of Order-specific Nuclear Organization in the Mammalian Thalamus. Nat. Neurosci. 20: 516-528. (PMCID: PMC5374008)

6.    Sultan, K.T.*, Han, Z.*, Zhang, X.-J.*, Xianyu, A., Li, Z., Huang, K., and Shi, S.-H. (2016) Clonally Related GABAergic Interneurons Do Not Randomly Disperse But Frequently Form Local Clusters in the Forebrain. (* Co-first author) Neuron 92: 31-44. (PMCID: PMC5066572)

7.    He, S., Li, Z., Ge, S., Yu, Y.-C., and Shi, S.-H. (2015) Inside-out Radial Migration Facilitates Lineage-dependent Microcircuit Assembly in the Neocortex. Neuron 86: 1159-1166. (PMCID: PMC4458701)

8.    Gao, P., Postiglione Pia, M., Krieger, T.G., Hernandez, L., T., Wang, C., Han, Z., Streicher, C., Papusheva, E., Insolera, R., Chugh, K., Kodish, O., Huang, K., Simons, B.D., Luo, L., Hippenmeyer, S., and Shi, S.-H. (2014) Deterministic Progenitor Behavior and Unitary Production of Neurons in the Neocortex. Cell 159: 775-788. (PMCID: PMC4225456)

9.    Insolera, R., Bazzi, H., W. Shao, Anderson, K.V., and Shi, S.-H. (2014) Cortical Neurogenesis in the Absence of Centrioles. Nat. Neurosci. 17: 1528-1535. (PMCID: PMC4213237)

10. Xu, H.-T., Han Z., Gao, P., He, S., Li, Z., Shi, W., Kordish, O., Shao, W., Brown, K.N., Huang, K., and Shi. S-H. (2014) Lineage-dependent Structural and Functional Organization of the Hippocampus. Cell 157: 1552-1564. (PMCID: PMC4120073)

11. Yu, Y.-C., He, S., Chen, S., Fu, Y., Brown, K.N., Yao, X.H., Ma, J., Gao, K.P., Sosinsky, G.E., Huang, K., and Shi, S.-H. (2012) Preferential Electric Coupling Regulates Neocortical Lineage-dependent Microcircuit Assembly. Nature 486: 113-7. (PMCID: PMC3599787)

12. Brown, K.N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Ding, L., Zhang, X.-J., Cruz, A. L., Saur, D., Anderson, S.A., Huang, K., and Shi, S.-H. (2011) Clonal Production and Organization of Inhibitory Interneurons in the Neocortex. Science 334: 480-486. (PMCID: PMC3304494)

13. Wang, X., Tsai, J.-W., Imai, J.H., Lin, W.-N., Valle, R.B., and Shi, S.-H. (2009) Asymmetric Centrosome Inheritance Maintains Neural Progenitors in the Neocortex. Nature 461: 947-955. (PMCID: PMC2764320)

14.  Yu, Y.-C., Bultje, R.S., Wang, X., and Shi, S.-H. (2009) Specific Synapses Develop Preferentially among Sister Excitatory Neurons in the Neocortex. Nature 458: 501-504.  (PMCID: PMC2727717)

 

 

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