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董晨

姓名:董晨

 

邮箱:

chendong@tsinghua.edu.cn

 

学科方向:

免疫学

 

研究方向:

董教授主要致力于免疫学的研究,重点探讨免疫耐受和免疫应答的分子调控机制,以理解自身免疫和过敏疾病的发病机理,并探索新型肿瘤免疫治疗.董晨教授是 Th17 细胞分化、调节和功能研究领域的奠基者和研究权威之一,并在 Tfh 和 Tfr 细胞的发现和研究中,做出了开创性贡献。他的主要研究领域包括:

1. T细胞分化和功能调控;

2. 细胞因子在炎症的功能及其机制;

3. 免疫耐受与肿瘤免疫治疗

 

代表性科研论文:

1. Liu, X.,Wang, Y., Lu, H., Li, J., Yan, X., Xiao, M., Hao, J., Hoang, O. N., Khong, H., Chen, T., Huang, R., Wu, J., Zhao, Q., Wu, Q., Xu, S., Wang, X., Jin, W., Yu, S., Wang, Y., Wei, L., Wang, A., Zhong, B., Ni, L., Liu, X., Nurieva, R., Ye, L., Tian, Q., Bian, X.-W. and Dong, C. (2019) Genome-wide analysis identifies Nr4a1 as a key mediator of T cell dysfunction. Nature. 567:525-529.

2. Su, Y., Huang, J., Zhao, X., Lu, H., Wang, W., Yang, X. O., Shi, Y., Wang, X., Lai, Y. and Dong, C. (2019) Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. (2019) Science Immunology. 4:36.

3. Xu, W., Zhao, X., Wang, X., Feng, H., Gou, M., Jin, W., Wang, X., Liu, X. and Dong, C. The transcription factor Tox2 drives T follicular helper cell development via regulating chromatin accessibility. (2019) Immunity. 51:826-839

4. Chang D, Xing Q, Su Y, Zhao X, Xu W, Wang X, Dong C. (2020). The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation. Immunity, 53(3):614-626.e4.

5. Wang X, Ni L, Wan S, Zhao X, Ding X, Dejean A, Dong C. (2020). Febrile temperature critically controls the differentiation and pathogenicity of T helper 17 cells. Immunity, 52(2):328-341

6. Ni L, Ye F, Cheng ML, Feng F, Deng YQ, Zhao H, Wei P, Ge Ji, Gou M, Li X, Sun L, Cao T, Wang P, Zhou C, Zhang R, Liang R, Guo H, Wang X, Qin CF, Chen F, Dong C. (2020). Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals. Immunity, 2020, (20) 30181-3

7. Dong, C. Seventeen on inflammation (Commentary) (2020) Nature Immunology 21:821-822.

8. Sun, L., Zhao, X., Liu, X., Zhong, B., Tang, H., Jin, W., Clevers, H., Wang, H., Wang, X. and Dong, C. Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription. (2021) Cell Reports. 35:109188.

9. Angkasekwinai, P. and Dong, C. IL-9-producing T cells: potential players in allergy and cancer. (Review)(2021) Nature Review Immunology. 21:37-48

10. Dong, C. Cytokine regulation and function in T cells. (Review) (2021) Annual Review of Immunology. 39:51-76

11. Huang J, Lee HY, Zhao X, Han J, Su Y, Sun Q, Shao J, Ge J, Zhao Y, Bai X, He Y, Wang X, Wang X, Dong C. (2021). Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93. Immunity, 54(4):673-686.

12. Dong, C. Defining the TH17 cell lineage. (Journal Club) (2021) Nature Review of Immunology 21: 618.

13. Chi, X., Jin, W., Bai, X., Zhao, X., Shao, J., Li, J., Sun, Q., Su, B., Wang, X., Yang, X. O. and Dong, C. RORa is critical for mTORC1 activity in T cell-mediated colitis. (2021) Cell Reports 36:109682.

14. Wan, S., Ni, L., Zhao, X., Liu, X., Xu, W., Jin, W., Wang, X. and Dong, C. Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation. (2021) Immunity 54:2740-2755. 

 

 

 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
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