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向烨

 

电子邮件:yxiang@tsinghua.edu.cn

电话:+86-10-62772587(实验室)

 

研究方向:

  课题组长期致力于病毒组装与入侵分子机制研究。系统研究了包括SARS冠状病毒、流感病毒以及一些甲病毒入侵宿主细胞分子机制(Cell2023mBio2022Commun. Biology, 2022Nature2021PLoS Path.2021Cell Reports2019PLoS Path.2018Cell Research2017),同时解析了一些复杂病毒的组装机制(Nature Commun.2023JVI2023Cell Research2019Nature Commun.2019PNAS2019Nature2016),为相关疫苗及药物研发提供理论指导作用。目前课题组专注两个方向:1. 一些重要囊膜病毒与受体分子的相互作用,以及基于结构的病毒疫苗抗原及药物开发;2. 病毒组装分子机制。

 

代表性科研论文:

(1) Cao, Duanfang; Ma, Bingting; Cao, Ziyi; Zhang, Xinzheng*; Xiang, Ye*; Structure of Semliki Forest virus in complex with its receptor VLDLR, Cell, 2023, 186(10): 2208-2218

(2) Jia, Qi; Xiang, Ye*; Cryo-EM structure of a bacteriophage M13 mini variant, Nature Communications, 2023, 14(1): 5421 

(3) Chen, Silian; Rong, Miao; Lv, Yun; Zhu, Deyu*; Xiang, Ye*; Regulation of cGAS activity by RNAmodulated phase separation, EMBO reports, 2023, 24(2): e51800

(4) Liu, Zhe; Xiang, Ye*; Structural studies of the nucleus-like assembly of jumbo bacteriophage 201φ2-1, Frontiers in Microbiology, 2023, 14: 1170112

(5) Li, Haining; Liu, Qi; Shao, Luyuan; Xiang, Ye*; Structural Insights into the Assembly of the African Swine Fever Virus Inner Capsid, Journal of Virology, 2023, 97(6): e0026823

(6) Tong, Liangqin; Wang, Lin; Liao, Shumin; Xiao, Xiaoping; Qu, Jing; Wu, Chunli; Zhu, Yibin; Tai, Wanbo; Huang, Yanhong; Wang, Penghua; Li, Liang; Zhang, Renli; Xiang, Ye*; Cheng, Gong*; A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry, MBio, 2022, 13(4): e0148522

(7) Ma, Bingting; Huang, Cuiqing; Ma, Jun; Xiang, Ye*; Zhang, Xinzheng*; Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3, Nature, 2021, 598(7882): 677- 681

(8) Watson, Avia; Li, Hao; Ma, Bingting; Weiss, Ronen; Bendayan, Daniele; Abramovitz, Lilach; Ben-Shalom, Noam; Mor, Michael; Pinko, Erica; Oz, Michal Bar; Wang, Zhenqi; Du, Fengjiao; Lu, Yu; Rybniker, Jan; Dahan, Rony; Huang, Hairong; Barkan, Daniel; Xiang, Ye*; Javid, Babak*; Freund, Natalia T.*; Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis, Nature Communications, 2021, 12(1): 602

(9) Huang, Liang; Xiang, Ye*; Structures of the tailed bacteriophages that infect Gram- positive bacteria, Current Opinion in Virology, 2020, 45: 65-74

(10) Gao, Jingjing; Gui, Miao*; Xiang, Ye*; Structural intermediates in the low pH-induced transition of influenza hemagglutinin, PLoS Pathogens, 2020, 16(11): e1009062

(11) Wang, Lin; Wang, Ruoke; Wang, Lei; Ben, Haijing; Yu, Lei; Gao, Fei; Shi, Xuanling; Yin, Chibiao; Zhang, Fuchun; Xiang, Ye*; Zhang, Linqi*; Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody, Cell Reports, 2019, 26(12): 3360-3368

(12) Wang, Wen; Chen, Silian; An, Byoungkwon; Huang, Kai; Bai, Tanxi; Xu, Mengyuan; Bellot, Gaetan; Ke, Yonggang; Xiang, Ye*; Wei, Bryan*; Complex wireframe DNA nanostructures from simple building blocks, Nature Communications, 2019, 10(1): 1067

(13) Xu, Jingwei; Dayan, Nir; Goldbourt, Amir*; Xiang, Ye*; Cryo-electron microscopy structure of the filamentous bacteriophage IKe, Proc Natl Acad Sci USA, 2019, 116(12): 5493-5498

(14) Liu, Qi; Ma, Bingting; Qian, Nianchao; Zhang, Fan; Tan, Xu; Lei, Jianlin; Xiang, Ye*; Structure of the African swine fever virus major capsid protein p72, Cell Research, 2019, 29(11): 953-955

(15) Song, Wenfei; Gui, Miao; Wang, Xinquan*; Xiang, Ye*; Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2, PLoS Pathogens, 2018, 14(8): e1007236

(16) Xu, Jingwei; Xiang, Ye*; Membrane Penetration by Bacterial Viruses. Journal of Virology, 2017, 91(13): e00162-17.

(17) Gui, Miao; Song, Wenfei; Zhou, Haixia; Xu, Jingwei; Chen, Silian; Xiang, Ye*; Wang, Xinquan*; Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding, Cell Research, 2017, 27(1): 119-129

(18) Misasi, J; Gilman, MS; Kanekiyo M; Gui, Miao; Cagigi, A; Mulangu, S; Corti, D; Ledgerwood, JE; Lanzavecchia, A; Cunningham, J; Muyembe-Tamfun, JJ; Baxa, U; Graham, BS; Xiang, Ye*; Sullivan, NJ*; McLellan, JS; Structural and molecular basis for Ebola virus neutralization by protective human antibodies, Science, 2016, 351(6279):1343-6

(19) Xu, Jingwei; Gui, Miao; Wang, Dianhong; Xiang, Ye*; The bacteriophage phi29 tail possesses a pore-forming loop for cell membrane penetration, Nature, 2016, 534(7608): 544-547

(20) Zhu, Deyu; Wang, Lijun; Shang, Guijun; Liu, Xue, Zhu, Jing; Lu, Defeng; Wang, Lei; Kan, Biao; Zhang, Jingren; Xiang, Ye*; Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates, Molecular Cell, 2014, 55(6):931-937

 

 

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