Ruiping XIAO

Email: xiaor(at)pku(dot)edu(dot)cn；

Telephone: +86-10-62757243；

Research Area:

My research focuses on revealing the molecular mechanisms of cardiometabolic and endocrine disorders, emphasizing translational research from target discovery and validation, mechanistic elucidation, to clinical studies. My current work centers on the role and translational potential of prolactin-prolactin receptor signaling in pain and chronic inflammatory diseases, as well as the pathological mechanisms and intervention strategies for major chronic conditions such as cancer cachexia and heart failure.

Selected Publications:

1. Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP. Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature. 494(7437): 375-379, 2013.

2. Zhang T, Zhang Y, Cui M, Jin L, Wang Y, Lv F, Liu Y, Zheng W, Shang H, Zhang J, Zhang M, Wu HK, Guo J, Zhang X, Hu X, Cao CM, Xiao RP. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat Med. 22(2): 175-182, 2016.

3. Zhang M, Gao H, Liu D, Zhong X, Shi X, Yu P, Jin L, Liu Y, Tnag Y, Song Y, Liu J, Hu X, Li CY, Song L, Qin J, Wu F, Jan F, Zhang Y, Xiao RP. CaMKII-δ9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA Repair. Nat Cell Biol. 21(9): 1152-1163, 2019.

4. Wu HK, Zhang Y, Cao CM, Hu X, Fang M, Yao Y, Jin L, Chen G, Jiang P, Zhang S, Song R, Peng W, Liu F, Guo J, Tang L, He Y, Shan D, Huang J, Zhou Z, Wang D, Lv F, Xiao RP. Glucose-sensitive myokine/cardiokine MG53 regulates systemic insulin response and metabolic homeostasis. Circulation. 139(7): 901–914, 2019.

5. Jiang P, Ren L, Zhi L, Yu Z, Lv F, Xu F, Peng W, Bai X, Cheng K, Quan L, Zhang X, Wang X, Zhang Y, Yang D, Hu X*, Xiao RP*. Negative Regulation of AMPK Signaling by High Glucose via E3 Ubiquitin Ligase MG53. Mol Cell. 81(3): 629-637, 2021.

6. Lv F, Wang Y, Shan D, Guo S, Chen G, Jin L, Zheng W, Feng H, Zeng X, Zhang S, Zhang Y, Hu X, Xiao RP. Blocking MG53S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury. Circ Res. 131(12): 962-976, 2022.

7. Liu X, Li S, Cui Q, Guo B, Ding W, Liu J, Quan L, Li X, Xie P, Jin L, Sheng Y, Chen W, Wang K, Zeng F, Qiu Y, Liu C, Zhang Y, Lv F, Hu X, Xiao RP. Activation of GPR81 by Lactate drives tumor-induced cachexia. Nat Metab. 6(4): 708-723, 2024.

8. Cui Q, Li S, Liu X, Liu J, Chen W, Sheng Y, Xie P, Jin L, Zeng F, Lv F, Hu X*, Xiao RP*. MIF-ACKR3 causes irreversible fat loss by impairing adipogenesis in cancer cachexia. Cell Metab. 37(4): 954-970, 2025.

9. Zhu L, Chen ZJ, Liu H, Wang G, Dynowski K, Zhang S, Wang L, Wang W, Gan X, Hou S, Guo R, Zhang X, Ruan H, Xu H, Zhao S, Zhang Y, Liu C, Zhu Y, Liu H, Xu B, Fang S, Tu S, Hu X, Chen X, Xiao RP. Safety and efficacy of subcutaneous injection with HMI-115 versus placebo in endometriosis-associated pain in premenopausal women: a multicentre, double-blind, randomised, proof-of-concept phase 2 trial. Lancet Obstet Gynaecol Womens Health. 1: e174–88, 2025.

10. Wang R, Xu S, Cui Q, Chen X, Wang X, Liu J, Liu J, Xin Y, Shen H, Lv F, Zhu L, Hu X, Xiao RP. Single-cell RNA sequencing identifies the prolactin receptor as a therapeutic target in adenomyosis. Signal Transduct Target Ther. 10(1): 258, 2025.