Anming Meng

E-mail：mengam(at)mail(dot)tsinghua(dot)edu(dot)cn

The MengLab primarily uses zebrafish and mice as model organisms to study the critical issues during early embryonic development in vertebrates, including cell fate determination, mesoderm induction and differentiation, and the key regulators of dorsal-ventral and anterior-posterior axis formation, aiming to uncover the underlying mechanisms.

Selected publications（* corresponding authors）

1.Sun K, Liu X, Xu R, Liu C, Meng A*, Lan X*. 2024. Mapping the chromatin accessibility landscape of zebrafish embryogenesis at single-cell resolution by SPATAC-seq. Nature Cell Biology, 26(7):1187-1199.

2.Shen W, Gong B, Xing C, Zhang L, Sun J, Chen Y, Yang C, Yan L, Chen L, Yao L, Li G, Deng H, Wu X, Meng A*. 2022. Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Cell, 185(26):4954-4970.

3.Jin H, Han Y, Wang H, Li JXH, Shen W, Zhang L, Chen L, Jia S, Yuan P, Chen H, Meng A*. 2022. The second polar body contributes to the fate asymmetry in the mouse embryo. National Science Review, 9(7).

4.Jia S, Meng A*. 2021. TGFβ family signaling and development. Development, 148(5).

5.Chen L, Xu  W, Liu  K, Jiang  Z, Han Y, Jin  H, Zhang  L, Shen W, Jia S, Sun Q, Meng A*. 2021. 5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos. Science Advances, 7(47).

6.Zhang L, Chen L, Chen J, Shen W, Meng A*. 2020. Mini-III RNase-based dual-color system for in vivo mRNA tracking. Development, 147(22).

7.Yan L, Chen J, Zhu X, Sun J, Wu X, Shen W, Zhang W, Tao Q*, Meng A*. 2018. Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates. Science, 362(6417).

8.Sun J, Yan L, Shen W, Meng A*. 2018. Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation. Development, 145(19).

9.Zhang J, Jiang Z, Liu X, Meng A*. 2016. Eph-ephrin signaling maintains the boundary dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development, 143(14):2603-2615.

10.Xue Y, Zheng XD, Huang L, Xu P, Ma Y, Min Z, Tao Q, Tao Y*, Meng A*. 2014. Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development. Nature Communications, 5:3766.