GUOQIANG CHEN PH.D.
Professor
1981-1985 BSc, South China University of Technology, Guangzhou, China
1986-1989 PhD, Graz University of Technology, Graz, Austria
1990-1992 Postdoc., University of Nottingham, UK
1992-1994 Postdoc., University of Alberta, Canada
1994-1997 Associate Professor, Tsinghua University
1997-Present Professor, Tsinghua University
Research interest
Synthetic Biology; Microbial Metabolic Engineering; Biological Materials; Industrial Biotechnology
Selected publications
1.Yiling Chen; Weike Guo; Rou Wen ; Guo-Qiang Chen. An automatic lytic system for downstream purification of PHA produced by Halomonas. Chemical Engineering Journal 517 (2025) 164425.
2.Mingwei Shao; Zhongnan Zhang; Xiaofan Jin; Jun Ding; Guo-Qiang Chen. An orthogonal transcription mutation system generating all transition mutations for accelerated protein evolution in vivo. Nature Communications | (2025) 16:6041.
3.Xinyu Chen; Jiangnan Chen; Xu Yan; Qiong Wu; Fuqing Wu; and Guo-Qiang Chen. Synthesis and characterization of a 3-hydroxybutyrate and 3-hydroxy-9-octadecenoate copolymer from engineered Halomonas. Green Chem., 2025, 27, 10182–10193.
4.Yiping Yuan; Helen Park; Fuqing Wu; Fang Yang ; Guo-Qiang Chen. Production and characterization of copolymers consisting of 3-hydroxybu-tyrate and increased 3-hydroxyvalerate by β-oxidation weakened Halomonas. Metabolic Engineering 89 (2025) 97–107.
5.Helen Park; Hongtao He; Xu Yan; Xu Liu; Nigel S. Scrutton; Guo-Qiang Chen. PHA is not just a bioplastic! Biotechnology Advances 71 (2024) 108320.
6.Lizhan Zhang; Jian-Wen Ye; Gang Li; Helen Park; Hao Luo; Yina Lin; Shaowei Li; Weinan Yang; Yuying Guan; Fuqing Wu; Wuzhe Huang; Qiong Wu; Nigel S. Scrutton; Jens Nielsen; Guo-Qiang Chen. A long-term growth stable Halomonas sp. deleted with multiple transposases guided by its metabolic network model Halo-ecGEM. Metabolic Engineering 84 (2024) 95–108
7.Ge Zhang; Weike Guo; Xueqing Yi; Zhongnan Zhang ; Lizhan Zhang; Xu Liu; Fuqing Wu; Qiong Wu; Guo-Qiang Chen. Engineered Halomonas for production of gamma-aminobutyric acid and 2-pyrrolidone. Bioresource Technology 413 (2024) 131448
8.Huan Wang; Jian-Wen Ye; Xinyu Chen; Yiping Yuan; Jingwen Shi; Xinyi Liu; Fang Yang; Yueyuan Ma; Jinchun Chen; Fuqing Wu; Yuxuan Lan; Qiong Wu; Yi Tong; Guo-Qiang Chen ; Production of PHA copolymers consisting of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx) by recombinant Halomonas bluephagenesis, Chemical Engineering Journal, 2023, 466(143261)
9.Li, Mengyi; Ma, Yueyuan; Zhang, Xu; Zhang, Lizhan; Chen, Xinyu; Ye, Jian-Wen; Chen, Guo-Qiang; Tailor-Made Polyhydroxyalkanoates by Reconstructing Pseudomonas Entomophila, Advanced Materials, 2021, 33(41)
10.Xiao-Ran Jiang; Xu Yan; Lin-Ping Yu; Xin-Yi Liu; Guo-Qiang Chen ; Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis, Nature Communications, 2021, 12(1)
11.Shu-jie Zhang; Zi-hua Li; Yu-dian Zhang; Jin Chen; Yuan Li; Fu-qing Wu; Wei Wang; Zong Jie Cui; Guo-Qiang Chen ; Ketone body 3-hydroxybutyrate ameliorates atherosclerosisvia receptor Gpr109a-mediated calcium influx, Advanced Science, 2021, 2021(2003410)
12.Hong Ma; Yiqing Zhao; Wuzhe Huang; Lizhan Zhang; Fuqing Wu; Jianwen Ye; Guo-Qiang Chen ; Rational flux-tuning of Halomonas bluephagenesis for co-production of bioplastic PHB and ectoine, Nature Communications, 2020, 11(1): 3313
13.Jian-Wen Ye; Yi-Na Lin; Xue-Qing Yi; Zhuo-Xuan Yu; Xu Liu; Guo-Qiang Chen ; Synthetic biology of extremophiles: a new wave of biomanufacturing, Trends in Biotechnology, 2023, 41(3): 342-357
14.Mengke Ji; Taoran Zheng; Ziyu Wang; Weijian Lai; Lizhan Zhang; Qianyi Zhang; Hongyi Yang; Si Meng; Wanghui Xu; Cuihuan Zhao; Qiong Wu; Guo-Qiang Chen ; PHB production from food waste hydrolysates by Halomonas bluephagenesis Harboring PHB operon linked with an essential gene, Metabolic Engineering, 2023, 77: 12-20
15.Yudian Zhang; Zihua Li; Xinyi Liu; Xinyu Chen; Shujie Zhang; Yuemeng Chen; Jiangnan Chen; Jin Chen; Fuqing Wu; Guo-Qiang Chen ; 3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice, Signal Transduction and Targeted Therapy, 2023, 8(1)
16.Yueyuan Ma; Xiangrui Zheng; Yina Lin; Lizhan Zhang; Yiping Yuan; Huan Wang; James Winterburn; Fuqing Wu; Qiong Wu; Jian-Wen Ye; Guo-Qiang Chen ; Engineering an oleic acid-induced system for Halomonas, E. coli and Pseudomonas, Metabolic Engineering, 2022, 72: 325-336
17.Fanfan Chen; Xinyi Liu; Xiyuan Ge; Yong Wang; Zifan Zhao; Xu Zhang; Guo-Qiang Chen; Yuchun Sun ; Porous Polydroxyalkanoates (PHA) Scaffolds with Antibacterial Property for Oral Soft Tissue Regeneration, Chemical Engineering Journal, 2022, 451(138899)
18.Xuan Wang; Jia-Ning Han; Xu Zhang; Yue-Yuan Ma; Yi-Na Lin; Huan Wang; Dian-Jie Li; Tao-Ran Zheng; Fu-Qing Wu; Jian-Wen Ye; Guo-Qiang Chen ; Reversible thermal regulation for bifunctional dynamic control of gene expression in Escherichia coli, Nature Communications, 2021, 12(1411): 1411
19.Wang, Ziyu; Qin, Qin; Zheng, Yifei; Li, Fajin; Zhao, Yiqing; Chen, Guo-Qiang ; Engineering the permeability of Halomonas bluephagenesis enhanced its chassis properties, Metabolic Engineering, 2021, 67: 53-66
20.Lin-Ping Yu; Xu Yan; Xu Zhang; Xiangbin Chen; Qiong Wu; Xiao-Ran Jiang; Guo-Qiang Chen ; Biosynthesis of functional polyhydroxyalkanoates by engineered Halomonas bluephagenesis, Metabolic Engineering, 2020, 59: 119-130
Awards
2023 International Metabolic Engineering Award
2022 Natural Resources Science and Technology Award - Science and Technology Progress Award
2021 Key Technology for Production of High Quality PLA and PHA together with Related Detivated Products
2012 “Basic Research on Application of Polyhydroxyalkanoates as a Tissue Engineering Material” Silver Medal of Scientific Achievement Awarded by Beijing Minicipal Government
2002 National Invention Silver Medal Award (Chinese Ministry of Sci and Technol)
Contact information
Tel：010－62783844 (office)
Email：chengq@tsinghua.edu.cn
