Zhibo LIU
Email: zbliu(at)pku(dot)edu(dot)cn；
Research Area:
My research focuses on developing radiochemical tools to address clinical challenges as well as energy and environmental issues. Specific research directions include:
1) Radiopharmaceutical Chemistry: Novel targets, innovative platform technologies, and new chelating agents.
2) Radioisotope Production, Purification, and Application.
3) Radiotherapy-Responsive Drugs and Neutron Capture Therapy (NCT) Drugs.
4) Radiation-Driven Activation and Transformation of Inert Matter.
Selected Publications:
1. Xi-Yang Cui#, Zhu Li#, Ziren Kong#, Yu Liu, Hao Meng, Zihao Wen, Changlun Wang, Junyi Chen, Mengxin Xu, Yiyan Li, Jingyue Gao, Wenjia Zhu, Zhixin Hao, Li Huo, Shaoyan Liu, Zhi Yang, Zhibo Liu*. Covalent Targeted Radioligands Potentiate Radionuclide Therapy. Nature 2024, 630, 206–213.
2. Qinyang Wang, Yupeng Wang, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*. A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature. 2020, 579, 421–426.
3. Qunfeng Fu#, Zhi Gu#, Siyong Shen#, Yifei Bai, Xianglin Wang, Mengxin Xu, Pengwei Sun, Junyi Chen, Dongxuan Li, Zhibo Liu*. Radiotherapy Activates Picolinium Prodrugs in Tumors. Nat. Chem. 2024, 16(8), 1348–1356.
4. Qunfeng Fu, Shuren Zhang, Siyong Shen, Zhi Gu, Junyi Chen, Dongfan Song, Pengwei Sun, Chunhong Wang, Zhibin Guo, Yunlong Xiao, Yi Qin Gao, Zijian Guo*, Zhibo Liu*. Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours. Nat. Biomed. Eng. 2024, 8, 1425–1435.
5. Chunhong Wang, Mengqi Chen, Mingzhe Zhang, Yu Qi, Junyi Chen, Yuanwei Zeng, Zhibo Liu*. Tumour-specific bioorthogonal synthesis of proteolysis-targeting chimeras and nanoparticles boosts T cell activity. Nat. Biomed. Eng. 2025, https://doi.org/10.1038/s41551-025-01560-z
6. Qiang Wei, Yuhxuan Lee, Weiqiu Liang, Xiaolei Chen, Bo-Shuai Mu, Xi-Yang Cui, Wangsuo Wu, Shuming Bai, Zhibo Liu*. Photocatalytic Direct Borylation of Carboxylic Acids. Nat Commun. 2022, 13, 7112.
7. Zexuan Ding#, Xiaozhe Yin#, Yuedan Zheng#, Yiyan Li#, Huanhuan Ge, Jianshu Feng, Ziyang Wang, Simiao Qiao, Qi Sun, Fashuo Yu, Zhanshan Hou, Yang-Xin Fu*, Zhibo Liu*. Single Atom Engineering for Radiotherapy-Activated Immune Agonist Prodrugs. Nat Commun. 2025, 16, 6021.
8. Qi Sun#, Yanping Zhao#, Simiao Qiao#, Kexuan Wang, Chuanjie Lu, Zizhu Zhang, Zhibin Guo, Zexuan Ding, Chunhong Wang, Jiyuan Li, Tong Liu, Zexian Zeng*, Zhibo Liu*. Boron neutron capture therapy preserves immune cells and induces robust anti-tumour immunity in preclinical mouse model. Nat Commun. 2026, 17, 1229.
9. Bo-Shuai Mu#, Yugang Zhang#, Mi Peng#, Zhiyu Tu, Zhenbo Guo, Siyong Shen, Yang Xu, Weiqiu Liang, Xianglin Wang, Meng Wang, Ding Ma*, Zhibo Liu*. Radiocatalytic Synthesis of Acetic Acid from CH4 and CO2. Angew Chem Int Ed. 2024, 63(44): e202407443.
10. Bo-Shuai Mu#, Yang Xu#, Zhiyu Tu, Weiqiu Liang, Jiahao Li, Xianglin Wang, Siyong Shen, Junyi Chen, Zhibo Liu*. Radiocatalytic ammonia synthesis from nitrogen and water. National Science Review. 2024, 11(11): nwae302.
